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TargetCannabinoid receptor 1
LigandBDBM50323613
Substrate/Competitorn/a
Meas. Tech.ChEMBL_645041
IC50 2000±n/a nM
Citation Kopka IELin LSJewell JPLanza TJFong TMShen CPLao ZJHa SCastonguay LGVan der Ploeg LGoulet MTHagmann WK Synthesis and cannabinoid-1 receptor binding affinity of conformationally constrained analogs of taranabant. Bioorg Med Chem Lett 20:4757-61 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cannabinoid receptor 1
Name:Cannabinoid receptor 1
Synonyms:CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:52868.96
Organism:Homo sapiens (Human)
Description:P21554
Residue:472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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  Blast E-value cutoff:
BDBM50323613
n/a
NameBDBM50323613
Synonyms:(+/-)-1-(3-(4-chlorobenzyl)-3-phenylpiperidin-1-yl)-2-methyl-2-(5-(trifluoromethyl)pyridin-2-yloxy)propan-1-one | CHEMBL1209749
TypeSmall organic molecule
Emp. Form.C28H28ClF3N2O2
Mol. Mass.516.982
SMILESCC(C)(Oc1ccc(cn1)C(F)(F)F)C(=O)N1CCCC(Cc2ccc(Cl)cc2)(C1)c1ccccc1
Structure
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