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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dipeptidyl peptidase 8 | ||
| Ligand | BDBM50324496 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_649273 (CHEMBL1218971) | ||
| Ki | 2.9±n/a nM | ||
| Citation |  Meng, W; Brigance, RP; Chao, HJ; Fura, A; Harrity, T; Marcinkeviciene, J; O'Connor, SP; Tamura, JK; Xie, D; Zhang, Y; Klei, HE; Kish, K; Weigelt, CA; Turdi, H; Wang, A; Zahler, R; Kirby, MS; Hamann, LG Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors. J Med Chem53:5620-8 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dipeptidyl peptidase 8 | |||
| Name: | Dipeptidyl peptidase 8 | ||
| Synonyms: | DPP8 | DPP8_HUMAN | DPRP-1 | DPRP1 | Dipeptidyl peptidase 8 (DPP-8) | Dipeptidyl peptidase 8 (DPP8) | Dipeptidyl peptidase 8/9 | Dipeptidyl peptidase IV-related protein 1 | Dipeptidyl peptidase VIII | Dipeptidyl peptidase VIII (DDP-VIII) | Prolyl dipeptidase DPP8 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 103342.62 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q6V1X1 | ||
| Residue: | 898 | ||
| Sequence: |
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| BDBM50324496 | |||
| n/a | |||
| Name | BDBM50324496 | ||
| Synonyms: | 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methyl-N-(oxazol-2-ylmethyl)imidazo[1,2-a]pyrimidine-2-carboxamide | CHEMBL1215163 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H16Cl2N6O2 | ||
| Mol. Mass. | 431.275 | ||
| SMILES | Cc1nc2nc(cn2c(c1CN)-c1ccc(Cl)cc1Cl)C(=O)NCc1ncco1 |(10.73,-.55,;9.42,-1.37,;8.06,-.65,;6.76,-1.46,;5.29,-1.03,;4.42,-2.29,;5.37,-3.51,;6.81,-2.99,;8.16,-3.72,;9.47,-2.92,;10.83,-3.64,;12.14,-2.83,;8.13,-5.26,;6.78,-5.99,;6.75,-7.53,;8.07,-8.34,;8.04,-9.87,;9.42,-7.58,;9.45,-6.05,;10.79,-5.3,;2.88,-2.34,;2.07,-1.03,;2.15,-3.7,;.61,-3.75,;-.12,-5.1,;-1.66,-5.12,;-2.12,-6.59,;-.87,-7.48,;.37,-6.56,)| | ||
| Structure | 
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