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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dipeptidyl peptidase 4 | ||
| Ligand | BDBM50324498 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_649272 (CHEMBL1218970) | ||
| Ki | 1.8±n/a nM | ||
| Citation |  Meng, W; Brigance, RP; Chao, HJ; Fura, A; Harrity, T; Marcinkeviciene, J; O'Connor, SP; Tamura, JK; Xie, D; Zhang, Y; Klei, HE; Kish, K; Weigelt, CA; Turdi, H; Wang, A; Zahler, R; Kirby, MS; Hamann, LG Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors. J Med Chem53:5620-8 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dipeptidyl peptidase 4 | |||
| Name: | Dipeptidyl peptidase 4 | ||
| Synonyms: | ADABP | ADCP2 | Adenosine deaminase complexing protein 2 | CD26 | CD_antigen=CD26 | DPP IV | DPP4 | DPP4_HUMAN | DPPIV | Dipeptidyl peptidase 4 (DDP-IV) | Dipeptidyl peptidase 4 (DPP IV) | Dipeptidyl peptidase 4 (DPP-4) | Dipeptidyl peptidase 4 (DPP4) | Dipeptidyl peptidase 4 (DPPIV) | Dipeptidyl peptidase 4 membrane form | Dipeptidyl peptidase 4 soluble form | Dipeptidyl peptidase IV | Dipeptidyl peptidase IV (DDP-4) | Dipeptidyl peptidase IV (DDP-IV) | Dipeptidyl peptidase IV (DPP IV) | Dipeptidyl peptidase IV membrane form | Dipeptidyl peptidase IV soluble form | Dipeptidyl peptidase-IV (DPP-4) | Dipeptidyl peptidase-IV (DPP-IV) | T-cell activation antigen CD26 | TP103 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 88271.01 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P27487 | ||
| Residue: | 766 | ||
| Sequence: |
| ||
| BDBM50324498 | |||
| n/a | |||
| Name | BDBM50324498 | ||
| Synonyms: | 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methyl-N-(1-methyl-1H-pyrazol-3-yl)imidazo[1,2-a]pyrimidine-2-carboxamide | CHEMBL1215165 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H17Cl2N7O | ||
| Mol. Mass. | 430.291 | ||
| SMILES | Cc1nc2nc(cn2c(c1CN)-c1ccc(Cl)cc1Cl)C(=O)Nc1ccn(C)n1 |(9.34,-1.14,;8.03,-1.95,;6.67,-1.24,;5.37,-2.04,;3.9,-1.61,;3.03,-2.88,;3.97,-4.1,;5.42,-3.58,;6.77,-4.31,;8.08,-3.5,;9.44,-4.22,;10.75,-3.41,;6.74,-5.84,;5.39,-6.58,;5.36,-8.12,;6.68,-8.92,;6.83,-10.51,;8.03,-8.16,;8.06,-6.63,;9.4,-5.89,;1.48,-2.92,;.68,-1.62,;.76,-4.28,;-.78,-4.33,;-1.64,-5.6,;-3.12,-5.16,;-3.16,-3.62,;-4.44,-2.76,;-1.72,-3.11,)| | ||
| Structure | 
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