Reaction Details | |||
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Target | Dipeptidyl peptidase 9 | ||
Ligand | BDBM50324515 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_649274 (CHEMBL1218972) | ||
Ki | 1.4±n/a nM | ||
Citation | Meng, W; Brigance, RP; Chao, HJ; Fura, A; Harrity, T; Marcinkeviciene, J; O'Connor, SP; Tamura, JK; Xie, D; Zhang, Y; Klei, HE; Kish, K; Weigelt, CA; Turdi, H; Wang, A; Zahler, R; Kirby, MS; Hamann, LG Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors. J Med Chem53:5620-8 (2010) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Dipeptidyl peptidase 9 | |||
Name: | Dipeptidyl peptidase 9 | ||
Synonyms: | DPP9 | DPP9_HUMAN | DPRP-2 | DPRP2 | Dipeptidyl peptidase 9 (DDP9) | Dipeptidyl peptidase 9 (DPP-9) | Dipeptidyl peptidase 9 (DPP9) | Dipeptidyl peptidase IV-related protein 2 | Dipeptidyl peptidase IX | Dipeptidyl peptidase IX (DDP-IX) | Dipeptidyl peptidase-like protein 9 | ||
Type: | Enzyme | ||
Mol. Mass.: | 98260.70 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q86TI2 | ||
Residue: | 863 | ||
Sequence: |
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BDBM50324515 | |||
n/a | |||
Name | BDBM50324515 | ||
Synonyms: | 6-(aminomethyl)-5-(2,4-dichlorophenyl)-N,N-diethyl-7-methylimidazo[1,2-a]pyrimidine-2-carboxamide | CHEMBL1214877 | ||
Type | Small organic molecule | ||
Emp. Form. | C19H21Cl2N5O | ||
Mol. Mass. | 406.309 | ||
SMILES | CCN(CC)C(=O)c1cn2c(c(CN)c(C)nc2n1)-c1ccc(Cl)cc1Cl |(-7.06,-1.08,;-6.33,.27,;-4.79,.32,;-3.98,-.99,;-4.71,-2.34,;-4.07,1.68,;-4.88,2.99,;-2.52,1.73,;-1.58,.51,;-.13,1.03,;1.22,.3,;2.53,1.1,;3.89,.38,;5.19,1.19,;2.48,2.65,;3.79,3.47,;1.12,3.37,;-.18,2.56,;-1.66,2.99,;1.19,-1.24,;-.16,-1.98,;-.19,-3.51,;1.13,-4.32,;1.1,-5.86,;2.48,-3.56,;2.5,-2.03,;3.85,-1.28,)| | ||
Structure |