Reaction Details |
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Target | Lysine-specific demethylase 4A |
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Ligand | BDBM50324530 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_649377 (CHEMBL1219075) |
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IC50 | 4400±n/a nM |
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Citation | Hamada, S; Suzuki, T; Mino, K; Koseki, K; Oehme, F; Flamme, I; Ozasa, H; Itoh, Y; Ogasawara, D; Komaarashi, H; Kato, A; Tsumoto, H; Nakagawa, H; Hasegawa, M; Sasaki, R; Mizukami, T; Miyata, N Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors. J Med Chem53:5629-38 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Lysine-specific demethylase 4A |
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Name: | Lysine-specific demethylase 4A |
Synonyms: | JHDM3A | JMJD2 | JMJD2A | JmjC domain-containing histone demethylation protein 3A | Jumonji domain-containing protein 2A | KDM4A | KDM4A_HUMAN | KIAA0677 | Lysine-specific demethylase 4A | Lysine-specific demethylase 4A (KDM4A) |
Type: | Enzyme |
Mol. Mass.: | 120647.83 |
Organism: | Homo sapiens (Human) |
Description: | O75164 |
Residue: | 1064 |
Sequence: | MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYD
DIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERK
YWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGM
WKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRH
KMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYG
KQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESELP
PRAGNEEECPEEDMEGVEDGEEGDLKTSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEDL
SSEQYEMTECPAALAPVRPTHSSVRQVEDGLTFPDYSDSTEVKFEELKNVKLEEEDEEEE
QAAAALDLSVNPASVGGRLVFSGSKKKSSSSLGSGSSRDSISSDSETSEPLSCRAQGQTG
VLTVHSYAKGDGRVTVGEPCTRKKGSAARSFSERELAEVADEYMFSLEENKKSKGRRQPL
SKLPRHHPLVLQECVSDDETSEQLTPEEEAEETEAWAKPLSQLWQNRPPNFEAEKEFNET
MAQQAPHCAVCMIFQTYHQVEFGGFNQNCGNASDLAPQKQRTKPLIPEMCFTSTGCSTDI
NLSTPYLEEDGTSILVSCKKCSVRVHASCYGVPPAKASEDWMCSRCSANALEEDCCLCSL
RGGALQRANDDRWVHVSCAVAILEARFVNIAERSPVDVSKIPLPRFKLKCIFCKKRRKRT
AGCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHKIPNLERAKGALQSIT
AGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQDCLQFGPPAEG
EVVQVRWTDGQVYGAKFVASHPIQMYQVEFEDGSQLVVKRDDVYTLDEELPKRVKSRLSV
ASDMRFNEIFTEKEVKQEKKRQRVINSRYREDYIEPALYRAIME
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BDBM50324530 |
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n/a |
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Name | BDBM50324530 |
Synonyms: | CHEMBL1215590 | tert-Butyl 3-({Hydroxy[9-(methylamino)nonanoyl]}amino)propanoicAcid Hydrochloride |
Type | Small organic molecule |
Emp. Form. | C13H26N2O4 |
Mol. Mass. | 274.3565 |
SMILES | CNCCCCCCCCC(=O)N(O)CCC(O)=O |
Structure |
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