| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
|---|
| Ligand | BDBM50324539 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_649390 (CHEMBL1219088) |
|---|
| IC50 | 1000±n/a nM |
|---|
| Citation |  Rossi, F; Valentina, C; Garavaglia, S; Sathyasaikumar, KV; Schwarcz, R; Kojima, S; Okuwaki, K; Ono, S; Kajii, Y; Rizzi, M Crystal structure-based selective targeting of the pyridoxal 5'-phosphate dependent enzyme kynurenine aminotransferase II for cognitive enhancement. J Med Chem53:5684-9 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
|---|
| Name: | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
|---|
| Synonyms: | AADAT_RAT | Aadat | Kat2 | Kynurenine/alpha-aminoadipate aminotransferase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 47788.12 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_826599 |
|---|
| Residue: | 425 |
|---|
| Sequence: | MNYSRFLTATSLARKTSPIRATVEIMSRAPKDIISLAPGSPNPKVFPFKSAVFTVENGST
IRFEGEMFQRALQYSSSYGIPELLSWLKQLQIKLHNPPTVNYSPNEGQMDLCITSGCQDG
LCKVFEMLINPGDTVLVNEPLYSGALFAMKPLGCNFISVPSDDCGIIPEGLKKVLSQWKP
EDSKDPTKRTPKFLYTIPNGNNPTGNSLTGDRKKEIYELARKYDFLIIEDDPYYFLQFTK
PWEPTFLSMDVDGRVIRADSLSKVISSGLRVGFITGPKSLIQRIVLHTQISSLHPCTLSQ
LMISELLYQWGEEGFLAHVDRAIDFYKNQRDFILAAADKWLRGLAEWHVPKAGMFLWIKV
NGISDAKKLIEEKAIEREILLVPGNSFFVDNSAPSSFFRASFSQVTPAQMDLVFQRLAQL
IKDVS
|
|
|
|---|
| BDBM50324539 |
|---|
| n/a |
|---|
| Name | BDBM50324539 |
|---|
| Synonyms: | (S)-(-)-9-(4-aminopiperazin-1-yl)-8-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-azaphenalene-5-carboxylic acid | CHEMBL1215659 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H19FN4O4 |
|---|
| Mol. Mass. | 362.3556 |
|---|
| SMILES | C[C@H]1COc2c(N3CCN(N)CC3)c(F)cc3c2n1cc(C(O)=O)c3=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
