| Reaction Details |
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 | Report a problem with these data |
| Target | Kynurenine--oxoglutarate transaminase 1 |
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| Ligand | BDBM50324539 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_649392 (CHEMBL1219090) |
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| IC50 | >30000±n/a nM |
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| Citation |  Rossi, F; Valentina, C; Garavaglia, S; Sathyasaikumar, KV; Schwarcz, R; Kojima, S; Okuwaki, K; Ono, S; Kajii, Y; Rizzi, M Crystal structure-based selective targeting of the pyridoxal 5'-phosphate dependent enzyme kynurenine aminotransferase II for cognitive enhancement. J Med Chem53:5684-9 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kynurenine--oxoglutarate transaminase 1 |
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| Name: | Kynurenine--oxoglutarate transaminase 1 |
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| Synonyms: | CCBL1 | Cysteine-S-conjugate beta-lyase | Glutamine--phenylpyruvate transaminase | KAT1_HUMAN | KYAT1 | Kynurenine Aminotransferase 1/Glutamine Transaminase K | Kynurenine--oxoglutarate transaminase 1 |
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| Type: | Aminotransferase; Lyase |
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| Mol. Mass.: | 47874.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant hKAT-1 was expressed and purified from Sf9 insect cells. |
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| Residue: | 422 |
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| Sequence: | MAKQLQARRLDGIDYNPWVEFVKLASEHDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFML
NQYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVTVGGYGALFTAFQALVDEGDEVII
IEPFFDCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVL
NTPNNPLGKVFSREELELVASLCQQHDVVCITDEVYQWMVYDGHQHISIASLPGMWERTL
TIGSAGKTFSATGWKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFR
QPSSYFVQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRKMPDLPGAVDE
PYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKWKV
EL
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| BDBM50324539 |
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| n/a |
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| Name | BDBM50324539 |
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| Synonyms: | (S)-(-)-9-(4-aminopiperazin-1-yl)-8-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-azaphenalene-5-carboxylic acid | CHEMBL1215659 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H19FN4O4 |
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| Mol. Mass. | 362.3556 |
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| SMILES | C[C@H]1COc2c(N3CCN(N)CC3)c(F)cc3c2n1cc(C(O)=O)c3=O |r| |
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| Structure | 
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