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TargetKynurenine Aminotransferase 1/Glutamine Transaminase K
LigandBDBM50324539
Substrate/Competitorn/a
Meas. Tech.ChEMBL_649393
IC50>30000±n/a nM
Citation Rossi FValentina CGaravaglia SSathyasaikumar KVSchwarcz RKojima SOkuwaki KOno SKajii YRizzi M Crystal structure-based selective targeting of the pyridoxal 5'-phosphate dependent enzyme kynurenine aminotransferase II for cognitive enhancement. J Med Chem 53:5684-9 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Kynurenine Aminotransferase 1/Glutamine Transaminase K
Name:Kynurenine Aminotransferase 1/Glutamine Transaminase K
Synonyms:Cysteine-S-conjugate beta-lyase | Glutamine--phenylpyruvate transaminase | Kynurenine--oxoglutarate transaminase 1
Type:Aminotransferase; Lyase
Mol. Mass.:47874.00
Organism:Homo sapiens (Human)
Description:Recombinant hKAT-1 was expressed and purified from Sf9 insect cells.
Residue:422
Sequence:
MAKQLQARRLDGIDYNPWVEFVKLASEHDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFML
NQYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVTVGGYGALFTAFQALVDEGDEVII
IEPFFDCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVL
NTPNNPLGKVFSREELELVASLCQQHDVVCITDEVYQWMVYDGHQHISIASLPGMWERTL
TIGSAGKTFSATGWKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFR
QPSSYFVQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRKMPDLPGAVDE
PYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKWKV
EL
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  Blast E-value cutoff:
BDBM50324539
n/a
NameBDBM50324539
Synonyms:(S)-(-)-9-(4-aminopiperazin-1-yl)-8-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-azaphenalene-5-carboxylic acid | CHEMBL1215659
TypeSmall organic molecule
Emp. Form.C17H19FN4O4
Mol. Mass.362.3556
SMILESC[C@H]1COc2c(N3CCN(N)CC3)c(F)cc3c2n1cc(C(O)=O)c3=O |r|
Structure
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