Reaction Details |
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Target | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
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Ligand | BDBM50416560 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_649389 (CHEMBL1219087) |
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IC50 | 1500±n/a nM |
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Citation | Rossi, F; Valentina, C; Garavaglia, S; Sathyasaikumar, KV; Schwarcz, R; Kojima, S; Okuwaki, K; Ono, S; Kajii, Y; Rizzi, M Crystal structure-based selective targeting of the pyridoxal 5'-phosphate dependent enzyme kynurenine aminotransferase II for cognitive enhancement. J Med Chem53:5684-9 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
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Name: | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial |
Synonyms: | 2-aminoadipate aminotransferase | 2-aminoadipate transaminase | AADAT | AADAT_HUMAN | Alpha-aminoadipate aminotransferase | KAT/AadAT | KAT2 | KYAT2 | Kynurenine aminotransferase II | Kynurenine aminotransferase II (KAT II) | Kynurenine--oxoglutarate aminotransferase II | Kynurenine--oxoglutarate transaminase 2 | Kynurenine--oxoglutarate transaminase II |
Type: | Enzyme |
Mol. Mass.: | 47353.09 |
Organism: | Homo sapiens (Human) |
Description: | Q8N5Z0 |
Residue: | 425 |
Sequence: | MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT
IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG
LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP
EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK
FRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ
LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV
KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL
IKESL
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BDBM50416560 |
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n/a |
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Name | BDBM50416560 |
Synonyms: | CHEMBL1215660 |
Type | Small organic molecule |
Emp. Form. | C17H19FN4O4 |
Mol. Mass. | 362.3556 |
SMILES | C[C@@H]1COc2c(N3CCN(N)CC3)c(F)cc3c2n1cc(C(O)=O)c3=O |r| |
Structure |
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