| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Fyn |
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| Ligand | BDBM4567 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_653001 (CHEMBL1226204) |
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| IC50 | >300000±n/a nM |
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| Citation |  Blair, JA; Rauh, D; Kung, C; Yun, CH; Fan, QW; Rode, H; Zhang, C; Eck, MJ; Weiss, WA; Shokat, KM Structure-guided development of affinity probes for tyrosine kinases using chemical genetics. Nat Chem Biol3:229-38 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Fyn |
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| Name: | Tyrosine-protein kinase Fyn |
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| Synonyms: | FYN | FYN_HUMAN | Proto-oncogene Syn | Proto-oncogene c-Fyn | SLK | SRC | Src-like kinase | p59-Fyn |
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| Type: | Enzyme |
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| Mol. Mass.: | 60762.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06241 |
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| Residue: | 537 |
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| Sequence: | MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG
LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW
EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET
TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC
RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT
LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR
ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY
TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE
RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
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| BDBM4567 |
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| n/a |
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| Name | BDBM4567 |
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| Synonyms: | 4-anilinoquinazoline deriv. 2 | BMC163482 Compound 1 | CHEMBL285063 | N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}prop-2-enamide | US9422297, PD168393 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H13BrN4O |
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| Mol. Mass. | 369.215 |
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| SMILES | Brc1cccc(Nc2ncnc3ccc(NC(=O)C=C)cc23)c1 |
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| Structure | 
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