Ki Summary

Reaction Details

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Target

Coagulation factor X

Ligand

BDBM50324745

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_651365 (CHEMBL1227185)

17±n/a nM

Citation

Anselm, L; Banner, DW; Benz, J; Zbinden, KG; Himber, J; Hilpert, H; Huber, W; Kuhn, B; Mary, JL; Otteneder, MB; Panday, N; Ricklin, F; Stahl, M; Thomi, S; Haap, W Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-[[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide] as a clinical candidate. Bioorg Med Chem Lett20:5313-9 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Coagulation factor X

Name:

Coagulation factor X

Synonyms:

F10 | FA10_RABIT

Type:

PROTEIN

Mol. Mass.:

53951.21

Organism:

Oryctolagus cuniculus

Description:

ChEMBL_1471174

Residue:

490

Sequence:

MANPLHLVLLGAALAGLLLSGSSVFISRRAANDVLARTRRANSFLEELKKGNLERECMEE
NCSYEEALEVFEDREKTNEFWNKYVDGDQCESNPCQNQGTCKDGLGMYTCSCVEGYEGQD
CEPVTRKLCSLDNGGCDQFCKEEENSVLCSCASGYTLGDNGKSCISTELFPCGKVTLGRW
RRSPATNSSEGPPEAPGPEQQDDGNLTATENPFNLLDSPEPPPEDDSSSLVRIVGGQDCR
DGECPWQALLVNEENEGFCGGTILSEYHVLTAAHCLHQAKRFKVRVGDRDTEHEEGNEET
HEVEVVVKHNRFVKETYDFDIAVLRLKTPITFRRNVAPACLPQKDWAESTLMAQKTGIVS
GFGRTHEMGRLSTTLKMLEVPYVDRNSCKRSSSFTITQNMFCAGYDARPEDACQGDSGGP
HVTRFRDTYFVTGIVSWGEGCARKGKFGVYTKVSNFLKWIEKSMRARAVPVAEAAGTPGP
TQPTIKGSPS

BDBM50324745

n/a

Name

BDBM50324745

Synonyms:

(3R,4R)-methyl 3-(5-chloropyridin-2-ylcarbamoyl)-4-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenylcarbamoyl)pyrrolidine-1-carboxylate | CHEMBL1221916

Type

Small organic molecule

Emp. Form.

C24H21ClFN5O5

Mol. Mass.

513.905

SMILES

COC(=O)N1C[C@@H]([C@H](C1)C(=O)Nc1ccc(cc1F)-n1ccccc1=O)C(=O)Nc1ccc(Cl)cn1 |r|

Structure