Reaction Details |
| Report a problem with these data |
Target | Vitamin K-dependent protein C |
---|
Ligand | BDBM50324743 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_651371 (CHEMBL1227191) |
---|
Ki | >33000±n/a nM |
---|
Citation | Anselm, L; Banner, DW; Benz, J; Zbinden, KG; Himber, J; Hilpert, H; Huber, W; Kuhn, B; Mary, JL; Otteneder, MB; Panday, N; Ricklin, F; Stahl, M; Thomi, S; Haap, W Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-[[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide] as a clinical candidate. Bioorg Med Chem Lett20:5313-9 (2010) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Vitamin K-dependent protein C |
---|
Name: | Vitamin K-dependent protein C |
Synonyms: | Activated protein C cofactor | Anticoagulant protein C | Apolipoprotein H | Autoprothrombin IIA | Blood coagulation factor XIV | Coagulation factor V | Coagulation factor V heavy chain | Coagulation factor V light chain | Endothelial protein C receptor | PROC | PROC_HUMAN | Proaccelerin, labile factor | Vitamin K-dependent protein C precursor |
Type: | Enzyme |
Mol. Mass.: | 52067.73 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 461 |
Sequence: | MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECI
EEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC
DCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVK
FPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGA
VLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDI
ALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVL
NFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLV
SWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
|
|
|
BDBM50324743 |
---|
n/a |
---|
Name | BDBM50324743 |
Synonyms: | (3R,4R)-1-(2,2-DIFLUORO-ETHYL)-PYRROLIDINE-3,4-DICARBOXYLIC ACID 3-[(5-CHLORO-PYRIDIN-2-YL)-AMIDE]-4-{[2-FLUORO-4-(2-OXO-2H-PYRIDIN-1-YL)-PHENYL]-AMIDE} | (3R,4R)-N3-(5-chloropyridin-2-yl)-1-(2,2-difluoroethyl)-N4-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)pyrrolidine-3,4-dicarboxamide | CHEMBL1221913 |
Type | Small organic molecule |
Emp. Form. | C24H21ClF3N5O3 |
Mol. Mass. | 519.903 |
SMILES | FC(F)CN1C[C@@H]([C@H](C1)C(=O)Nc1ccc(cc1F)-n1ccccc1=O)C(=O)Nc1ccc(Cl)cn1 |r| |
Structure |
|