| Reaction Details |
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 | Report a problem with these data |
| Target | Vitamin K-dependent protein C |
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| Ligand | BDBM50324744 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_651371 (CHEMBL1227191) |
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| Ki | >33000±n/a nM |
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| Citation |  Anselm, L; Banner, DW; Benz, J; Zbinden, KG; Himber, J; Hilpert, H; Huber, W; Kuhn, B; Mary, JL; Otteneder, MB; Panday, N; Ricklin, F; Stahl, M; Thomi, S; Haap, W Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-[[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide] as a clinical candidate. Bioorg Med Chem Lett20:5313-9 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Vitamin K-dependent protein C |
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| Name: | Vitamin K-dependent protein C |
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| Synonyms: | Activated protein C cofactor | Anticoagulant protein C | Apolipoprotein H | Autoprothrombin IIA | Blood coagulation factor XIV | Coagulation factor V | Coagulation factor V heavy chain | Coagulation factor V light chain | Endothelial protein C receptor | PROC | PROC_HUMAN | Proaccelerin, labile factor | Vitamin K-dependent protein C precursor |
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| Type: | Enzyme |
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| Mol. Mass.: | 52067.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 461 |
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| Sequence: | MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECI
EEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC
DCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVK
FPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGA
VLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDI
ALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVL
NFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLV
SWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
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| BDBM50324744 |
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| n/a |
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| Name | BDBM50324744 |
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| Synonyms: | (3R,4R)-N3-(5-chloropyridin-2-yl)-N4-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-1-isopropylpyrrolidine-3,4-dicarboxamide | CHEMBL1221915 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25ClFN5O3 |
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| Mol. Mass. | 497.949 |
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| SMILES | CC(C)N1C[C@@H]([C@H](C1)C(=O)Nc1ccc(cc1F)-n1ccccc1=O)C(=O)Nc1ccc(Cl)cn1 |r| |
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| Structure | 
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