Reaction Details |
| Report a problem with these data |
Target | Renin |
---|
Ligand | BDBM50325178 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_651750 (CHEMBL1228440) |
---|
IC50 | 2.4±n/a nM |
---|
Citation | Chen, A; Dubé, D; Dubé, L; Gagné, S; Gallant, M; Gaudreault, M; Grimm, E; Houle, R; Lacombe, P; Laliberté, S; Liu, S; MacDonald, D; Mackay, B; Martin, D; McKay, D; Powell, D; Lévesque, JF Addressing time-dependent CYP 3A4 inhibition observed in a novel series of substituted amino propanamide renin inhibitors, a case study. Bioorg Med Chem Lett20:5074-9 (2010) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Renin |
---|
Name: | Renin |
Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 45058.99 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 406 |
Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
|
|
|
BDBM50325178 |
---|
n/a |
---|
Name | BDBM50325178 |
Synonyms: | (R)-3-amino-N-(2-chloro-5-(3-methoxypropyl)benzyl)-N-cyclopropyl-2-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)benzyl)propanamide | CHEMBL1222884 |
Type | Small organic molecule |
Emp. Form. | C33H39Cl3N2O4 |
Mol. Mass. | 634.033 |
SMILES | COCCCc1ccc(Cl)c(CN(C2CC2)C(=O)[C@@H](CN)Cc2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)c1 |r| |
Structure |
|