| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin F |
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| Ligand | BDBM12311 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_656022 (CHEMBL1245066) |
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| IC50 | 1100±n/a nM |
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| Citation |  Liverton, NJ; Carroll, SS; Dimuzio, J; Fandozzi, C; Graham, DJ; Hazuda, D; Holloway, MK; Ludmerer, SW; McCauley, JA; McIntyre, CJ; Olsen, DB; Rudd, MT; Stahlhut, M; Vacca, JP MK-7009, a potent and selective inhibitor of hepatitis C virus NS3/4A protease. Antimicrob Agents Chemother54:305-11 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin F |
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| Name: | Cathepsin F |
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| Synonyms: | CATF_HUMAN | CATSF | CTSF |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53373.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_852650 |
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| Residue: | 484 |
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| Sequence: | MAPWLQLLSLLGLLPGAVAAPAQPRAASFQAWGPPSPELLAPTRFALEMFNRGRAAGTRA
VLGLVRGRVRRAGQGSLYSLEATLEEPPCNDPMVCRLPVSKKTLLCSFQVLDELGRHVLL
RKDCGPVDTKVPGAGEPKSAFTQGSAMISSLSQNHPDNRNETFSSVISLLNEDPLSQDLP
VKMASIFKNFVITYNRTYESKEEARWRLSVFVNNMVRAQKIQALDRGTAQYGVTKFSDLT
EEEFRTIYLNTLLRKEPGNKMKQAKSVGDLAPPEWDWRSKGAVTKVKDQGMCGSCWAFSV
TGNVEGQWFLNQGTLLSLSEQELLDCDKMDKACMGGLPSNAYSAIKNLGGLETEDDYSYQ
GHMQSCNFSAEKAKVYINDSVELSQNEQKLAAWLAKRGPISVAINAFGMQFYRHGISRPL
RPLCSPWLIDHAVLLVGYGNRSDVPFWAIKNSWGTDWGEKGYYYLHRGSGACGVNTMASS
AVVD
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| BDBM12311 |
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| n/a |
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| Name | BDBM12311 |
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| Synonyms: | (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide | 3-{[(1R,2S,5S)-3-[(2S)-2-[(tert-butylcarbamoyl)amino]-3,3-dimethylbutanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2-yl]formamido}-4-cyclobutyl-2-oxobutanamide | BOCEPREVIR | SCH 503034 | acs.jmedchem.1c00409_ST.355 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H45N5O5 |
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| Mol. Mass. | 519.6767 |
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| SMILES | CC(C)(C)NC(=O)N[C@H](C(=O)N1C[C@H]2[C@@H]([C@H]1C(=O)NC(CC1CCC1)C(=O)C(N)=O)C2(C)C)C(C)(C)C |r| |
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| Structure | 
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