| Reaction Details |
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 | Report a problem with these data |
| Target | NADPH oxidase 4 |
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| Ligand | BDBM4085 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_658093 (CHEMBL1249158) |
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| IC50 | 1580±n/a nM |
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| Citation |  Borbély, G; Szabadkai, I; Horváth, Z; Markó, P; Varga, Z; Breza, N; Baska, F; Vántus, T; Huszár, M; Geiszt, M; Hunyady, L; Buday, L; Orfi, L; Kéri, G Small-molecule inhibitors of NADPH oxidase 4. J Med Chem53:6758-62 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NADPH oxidase 4 |
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| Name: | NADPH oxidase 4 |
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| Synonyms: | KOX-1 | Kidney oxidase-1 | Kidney superoxide-producing NADPH oxidase | NOX4 | NOX4_HUMAN | RENOX | Renal NAD(P)H-oxidase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 66954.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_792879 |
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| Residue: | 578 |
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| Sequence: | MAVSWRSWLANEGVKHLCLFIWLSMNVLLFWKTFLLYNQGPEYHYLHQMLGLGLCLSRAS
ASVLNLNCSLILLPMCRTLLAYLRGSQKVPSRRTRRLLDKSRTFHITCGVTICIFSGVHV
AAHLVNALNFSVNYSEDFVELNAARYRDEDPRKLLFTTVPGLTGVCMVVVLFLMITASTY
AIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNISLP
EYFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAERLY
RYIRSNKPVTIISVMSHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLTMCP
TETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEES
LNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLH
NKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPRWKLLFDEIAKYNRGK
TVGVFCCGPNSLSKTLHKLSNQNNSYGTRFEYNKESFS
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| BDBM4085 |
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| n/a |
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| Name | BDBM4085 |
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| Synonyms: | 2,3,8,9-tetrahydroxy-5-[(4-nitrophenyl)methyl]-5,6-dihydrophenanthridin-6-one | Phenanthridinone deriv. 5g |
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| Type | Small organic molecule |
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| Emp. Form. | C20H14N2O7 |
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| Mol. Mass. | 394.3344 |
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| SMILES | Oc1cc2n(Cc3ccc(cc3)[N+]([O-])=O)c(=O)c3cc(O)c(O)cc3c2cc1O |
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| Structure | 
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