| Reaction Details |
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 | Report a problem with these data |
| Target | Ecdysone receptor |
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| Ligand | BDBM50326774 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_661762 (CHEMBL1251995) |
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| IC50 | 17500±n/a nM |
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| Citation |  Birru, W; Fernley, RT; Graham, LD; Grusovin, J; Hill, RJ; Hofmann, A; Howell, L; James, PJ; Jarvis, KE; Johnson, WM; Jones, DA; Leitner, C; Liepa, AJ; Lovrecz, GO; Lu, L; Nearn, RH; O'Driscoll, BJ; Phan, T; Pollard, M; Turner, KA; Winkler, DA Synthesis, binding and bioactivity of gamma-methylene gamma-lactam ecdysone receptor ligands: advantages of QSAR models for flexible receptors. Bioorg Med Chem18:5647-60 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ecdysone receptor |
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| Name: | Ecdysone receptor |
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| Synonyms: | 20-hydroxy-ecdysone receptor | 20E receptor | ECR_LUCCU | EcR | EcRH | Ecdysteroid receptor | NR1H1 | Nuclear receptor subfamily 1 group H member 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 82587.92 |
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| Organism: | Lucilia cuprina |
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| Description: | ChEMBL_661762 |
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| Residue: | 757 |
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| Sequence: | MMKRRWSNNGGFAALKMLEESSSEVTSSSNGLVLSSDINMSPSSLDSPVYGDQEMWLCND
SASYNNSHQHSVITSLQGCTSSLPAQTTIIPLSALPNSNNASLNNQNQNYQNGNSMNTNL
SVNTNNSVGGGGGGGGVPGMTSLNGLGGGGGSQVNNHNHSHNHLHHNSNSNHSNSSSHHT
NGHMGIGGGGGGLSVNINGPNIVSNAQQLNSLQASQNGQVIHANIGIHSIISNGLNHHHH
HHMNNSSMMHHTPRSESANSISSGRDDLSPSSSLNGFSTSDASDVKKIKKGPAPRLQEEL
CLVCGDRASGYHYNALTCEGCKGFFRRSVTKNAVYCCKFGHACEMDMYMRRKCQECRLKK
CLAVGMRPECVVPENQCAMKRREKKAQKEKDKIQTSVCATEIKKEILDLMTCEPPSHPTC
PLLPEDILAKCQARNIPPLSYNQLAVIYKLIWYQDGYEQPSEEDLKRIMSSPDENESQHD
ASFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHNSD
SIFFANNRSYTRDSYKMAGMADNIEDLLHFCRQMYSMKVDNVEYALLTAIVIFSDRPGLE
EAELVEAIQSYYIDTLRIYILNRHCGDPMSLVFFAKLLSILTELRTLGNQNAEMCFSLKL
KNRKLPKFLEEIWDVHAIPPSVQSHIQATQAEKAAQEAQATTSAISAAATSSSSINTSMA
TSSSSSLSPSAASTPNGGAVDYVGTDMSMSLVQSDNA
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| BDBM50326774 |
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| n/a |
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| Name | BDBM50326774 |
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| Synonyms: | 3-benzoyl-4-methyl-5-methylene-1-(3-(trifluoromethyl)phenyl)-1H-pyrrol-2(5H)-one | CHEMBL1254303 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H14F3NO2 |
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| Mol. Mass. | 357.3259 |
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| SMILES | CC1=C(C(=O)c2ccccc2)C(=O)N(C1=C)c1cccc(c1)C(F)(F)F |c:1| |
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| Structure | 
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