Reaction Details |
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Target | Sterol 26-hydroxylase, mitochondrial |
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Ligand | BDBM50155468 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_662819 (CHEMBL1252219) |
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IC50 | 4330±n/a nM |
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Citation | Aboraia, AS; Makowski, B; Bahja, A; Prosser, D; Brancale, A; Jones, G; Simons, C Synthesis and CYP24A1 inhibitory activity of (E)-2-(2-substituted benzylidene)- and 2-(2-substituted benzyl)-6-methoxy-tetralones. Eur J Med Chem45:4427-34 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sterol 26-hydroxylase, mitochondrial |
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Name: | Sterol 26-hydroxylase, mitochondrial |
Synonyms: | CP27A_HUMAN | CYP27 | CYP27A1 |
Type: | PROTEIN |
Mol. Mass.: | 60250.67 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_430507 |
Residue: | 531 |
Sequence: | MAALGCARLRWALRGAGRGLCPHGARAKAAIPAALPSDKATGAPGAGPGVRRRQRSLEEI
PRLGQLRFFFQLFVQGYALQLHQLQVLYKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQ
EGKYPVRNDMELWKEHRDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNE
VIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVTF
VRSIGLMFQNSLYATFLPKWTRPVLPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAA
GPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEA
LHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPK
NTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRR
IAELEMQLLLARLIQKYKVVLAPETGELKSVARIVLVPNKKVGLQFLQRQC
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BDBM50155468 |
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n/a |
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Name | BDBM50155468 |
Synonyms: | 2-[1-(2-Bromo-phenyl)-meth-(E)-ylidene]-6-methoxy-3,4-dihydro-2H-naphthalen-1-one | 2-[1-(2-bromophenyl)methylidene]-6-methoxy-3,4-dihydro-2H-naphthalen-1-one | CHEMBL363682 |
Type | Small organic molecule |
Emp. Form. | C18H15BrO2 |
Mol. Mass. | 343.215 |
SMILES | COc1ccc2C(=O)\C(CCc2c1)=C\c1ccccc1Br |
Structure |
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