Reaction Details |
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Target | Mitogen-activated protein kinase 14 |
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Ligand | BDBM50326907 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_663241 (CHEMBL1251348) |
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IC50 | 299±n/a nM |
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Citation | Wu, B; Wang, HL; Pettus, L; Wurz, RP; Doherty, EM; Henkle, B; McBride, HJ; Saris, CJ; Wong, LM; Plant, MH; Sherman, L; Lee, MR; Hsieh, F; Tasker, AS Discovery of pyridazinopyridinones as potent and selective p38 mitogen-activated protein kinase inhibitors. J Med Chem53:6398-411 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 14 |
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Name: | Mitogen-activated protein kinase 14 |
Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 41286.76 |
Organism: | Homo sapiens (Human) |
Description: | Q16539 |
Residue: | 360 |
Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM50326907 |
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n/a |
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Name | BDBM50326907 |
Synonyms: | 8-(2,4-Difluorophenyl)-3-((4-fluorophenyl)(methyl)amino)-1-methylpyrido[3,2-d]pyridazin-2(1H)-one | CHEMBL1253981 |
Type | Small organic molecule |
Emp. Form. | C21H15F3N4O |
Mol. Mass. | 396.3652 |
SMILES | CN(c1ccc(F)cc1)c1cc2cnnc(-c3ccc(F)cc3F)c2n(C)c1=O |
Structure |
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