Found 940 hits with Last Name = 'wang' and Initial = 'hl' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Induced myeloid leukemia cell differentiation protein Mcl-1
(Homo sapiens (Human)) | BDBM50196032
((N-[(2-tert-butylbenzenesulfonyl)phenyl]-2,3,4-tri...)Show SMILES CC(C)c1ccccc1Cc1cc(C(=O)Nc2ccc(cc2)S(=O)(=O)c2ccccc2C(C)(C)C)c(O)c(O)c1O Show InChI InChI=1S/C33H35NO6S/c1-20(2)25-11-7-6-10-21(25)18-22-19-26(30(36)31(37)29(22)35)32(38)34-23-14-16-24(17-15-23)41(39,40)28-13-9-8-12-27(28)33(3,4)5/h6-17,19-20,35-37H,18H2,1-5H3,(H,34,38) | PDB
MMDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FAM-Bid BH3 peptide binding to recombinant human MCL1 by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112201
BindingDB Entry DOI: 10.7270/Q26D5XMR |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50196032
((N-[(2-tert-butylbenzenesulfonyl)phenyl]-2,3,4-tri...)Show SMILES CC(C)c1ccccc1Cc1cc(C(=O)Nc2ccc(cc2)S(=O)(=O)c2ccccc2C(C)(C)C)c(O)c(O)c1O Show InChI InChI=1S/C33H35NO6S/c1-20(2)25-11-7-6-10-21(25)18-22-19-26(30(36)31(37)29(22)35)32(38)34-23-14-16-24(17-15-23)41(39,40)28-13-9-8-12-27(28)33(3,4)5/h6-17,19-20,35-37H,18H2,1-5H3,(H,34,38) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 290 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FAM-Bid BH3 peptide binding to recombinant human BCL2 by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112201
BindingDB Entry DOI: 10.7270/Q26D5XMR |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50196032
((N-[(2-tert-butylbenzenesulfonyl)phenyl]-2,3,4-tri...)Show SMILES CC(C)c1ccccc1Cc1cc(C(=O)Nc2ccc(cc2)S(=O)(=O)c2ccccc2C(C)(C)C)c(O)c(O)c1O Show InChI InChI=1S/C33H35NO6S/c1-20(2)25-11-7-6-10-21(25)18-22-19-26(30(36)31(37)29(22)35)32(38)34-23-14-16-24(17-15-23)41(39,40)28-13-9-8-12-27(28)33(3,4)5/h6-17,19-20,35-37H,18H2,1-5H3,(H,34,38) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 1.11E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of FAM-Bid BH3 peptide binding to recombinant human BCL-XL by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112201
BindingDB Entry DOI: 10.7270/Q26D5XMR |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50517420
(CHEMBL4513589)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CC1)n(CC1(N)CC1)c2=O |r| Show InChI InChI=1S/C23H26N6O2/c1-12-17-15(19(30)25-12)10-16(26-17)13-4-3-5-14-18(13)27-21(28-22(2)6-7-22)29(20(14)31)11-23(24)8-9-23/h3-5,10,12,26H,6-9,11,24H2,1-2H3,(H,25,30)(H,27,28)/t12-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ... |
J Med Chem 62: 1523-1540 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01733
BindingDB Entry DOI: 10.7270/Q25X2D97 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM192642
(US9187486, 87)Show SMILES C[C@@H]1CC[C@H](N)CN1c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C23H23F2N7/c1-14-5-6-15(26)13-31(14)21-9-10-27-12-20(21)29-23-28-11-16-7-8-19(30-32(16)23)22-17(24)3-2-4-18(22)25/h2-4,7-12,14-15H,5-6,13,26H2,1H3,(H,28,29)/t14-,15+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.0210 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant Pim1 (unknown origin) by electrochemiluminescence assay |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM192574
(US9187486, 37 | US9187486, 39 | US9187486, 60)Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C23H23F2N7/c1-14-9-15(26)13-31(12-14)21-7-8-27-11-20(21)29-23-28-10-16-5-6-19(30-32(16)23)22-17(24)3-2-4-18(22)25/h2-8,10-11,14-15H,9,12-13,26H2,1H3,(H,28,29)/t14-,15+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.0240 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant Pim1 (unknown origin) by electrochemiluminescence assay |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-3
(Homo sapiens (Human)) | BDBM192574
(US9187486, 37 | US9187486, 39 | US9187486, 60)Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C23H23F2N7/c1-14-9-15(26)13-31(12-14)21-7-8-27-11-20(21)29-23-28-10-16-5-6-19(30-32(16)23)22-17(24)3-2-4-18(22)25/h2-8,10-11,14-15H,9,12-13,26H2,1H3,(H,28,29)/t14-,15+/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.0270 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Pim3 (unknown origin) |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50517431
(CHEMBL4471849)Show SMILES CC(c1cn(C)cn1)n1c(NC2(C)CC2)nc2c(cccc2c1=O)-c1cc2C(=O)N[C@H](C)c2[nH]1 |r| Show InChI InChI=1S/C25H27N7O2/c1-13-20-17(22(33)27-13)10-18(28-20)15-6-5-7-16-21(15)29-24(30-25(3)8-9-25)32(23(16)34)14(2)19-11-31(4)12-26-19/h5-7,10-14,28H,8-9H2,1-4H3,(H,27,33)(H,29,30)/t13-,14?/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ... |
J Med Chem 62: 1523-1540 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01733
BindingDB Entry DOI: 10.7270/Q25X2D97 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50517433
(CHEMBL4450494)Show SMILES C[C@@H](c1cn(C)cn1)n1c(NC2(C)CC2)nc2c(cccc2c1=O)-c1cc2C(=O)N[C@H](C)c2[nH]1 |r| Show InChI InChI=1S/C25H27N7O2/c1-13-20-17(22(33)27-13)10-18(28-20)15-6-5-7-16-21(15)29-24(30-25(3)8-9-25)32(23(16)34)14(2)19-11-31(4)12-26-19/h5-7,10-14,28H,8-9H2,1-4H3,(H,27,33)(H,29,30)/t13-,14+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ... |
J Med Chem 62: 1523-1540 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01733
BindingDB Entry DOI: 10.7270/Q25X2D97 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM192648
(US9187486, 100)Show SMILES C[C@@H]1CCN(C[C@H]1N)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C23H23F2N7/c1-14-8-10-31(13-18(14)26)21-7-9-27-12-20(21)29-23-28-11-15-5-6-19(30-32(15)23)22-16(24)3-2-4-17(22)25/h2-7,9,11-12,14,18H,8,10,13,26H2,1H3,(H,28,29)/t14-,18-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.0350 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant Pim1 (unknown origin) by electrochemiluminescence assay |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM192640
(US9187486, 85)Show SMILES C[C@H]1CC[C@H](N)CN1c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C23H23F2N7/c1-14-5-6-15(26)13-31(14)21-9-10-27-12-20(21)29-23-28-11-16-7-8-19(30-32(16)23)22-17(24)3-2-4-18(22)25/h2-4,7-12,14-15H,5-6,13,26H2,1H3,(H,28,29)/t14-,15-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.0370 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant Pim1 (unknown origin) by electrochemiluminescence assay |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50200531
(CHEMBL3950251)Show SMILES N[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C22H22F2N8O/c23-13-2-1-3-14(24)20(13)17-5-4-12-8-28-22(32(12)30-17)29-18-9-27-7-6-19(18)31-10-15(25)21(33)16(26)11-31/h1-9,15-16,21,33H,10-11,25-26H2,(H,28,29)/t15-,16+,21+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant Pim1 (unknown origin) by electrochemiluminescence assay |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50174162
(CHEMBL3808669)Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(NCCCC2)nc13 |r| Show InChI InChI=1S/C20H21N5O/c1-11-19-21-8-3-2-5-12-10-22-20(26)14-9-16(24-17(12)14)13-6-4-7-15(23-11)18(13)25-19/h4,6-7,9,12,24H,2-3,5,8,10H2,1H3,(H,21,25)(H,22,26)/t12-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human full-length Pim2 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser 112 preincubated fo... |
ACS Med Chem Lett 7: 408-12 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50517428
(CHEMBL4568404)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CC1)n(c2=O)C1(C)CC1 |r| Show InChI InChI=1S/C23H25N5O2/c1-12-17-15(19(29)24-12)11-16(25-17)13-5-4-6-14-18(13)26-21(27-22(2)7-8-22)28(20(14)30)23(3)9-10-23/h4-6,11-12,25H,7-10H2,1-3H3,(H,24,29)(H,26,27)/t12-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ... |
J Med Chem 62: 1523-1540 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01733
BindingDB Entry DOI: 10.7270/Q25X2D97 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50517428
(CHEMBL4568404)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CC1)n(c2=O)C1(C)CC1 |r| Show InChI InChI=1S/C23H25N5O2/c1-12-17-15(19(29)24-12)11-16(25-17)13-5-4-6-14-18(13)26-21(27-22(2)7-8-22)28(20(14)30)23(3)9-10-23/h4-6,11-12,25H,7-10H2,1-3H3,(H,24,29)(H,26,27)/t12-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ... |
J Med Chem 62: 1523-1540 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01733
BindingDB Entry DOI: 10.7270/Q25X2D97 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50174153
(CHEMBL3808887)Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(N[C@H](C)\C=C\C2)nc13 |r,t:25| Show InChI InChI=1S/C21H21N5O/c1-11-5-3-6-13-10-22-21(27)15-9-17(25-18(13)15)14-7-4-8-16-19(14)26-20(23-11)12(2)24-16/h3-5,7-9,11,13,25H,6,10H2,1-2H3,(H,22,27)(H,23,26)/b5-3+/t11-,13+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human full-length Pim2 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser 112 preincubated fo... |
ACS Med Chem Lett 7: 408-12 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50517429
(CHEMBL4436404)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CC1)n(CC1CC1)c2=O |r| Show InChI InChI=1S/C23H25N5O2/c1-12-18-16(20(29)24-12)10-17(25-18)14-4-3-5-15-19(14)26-22(27-23(2)8-9-23)28(21(15)30)11-13-6-7-13/h3-5,10,12-13,25H,6-9,11H2,1-2H3,(H,24,29)(H,26,27)/t12-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ... |
J Med Chem 62: 1523-1540 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01733
BindingDB Entry DOI: 10.7270/Q25X2D97 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50174168
(CHEMBL3810121)Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(NC\C=C/C2)nc13 |r,c:24| Show InChI InChI=1S/C20H19N5O/c1-11-19-21-8-3-2-5-12-10-22-20(26)14-9-16(24-17(12)14)13-6-4-7-15(23-11)18(13)25-19/h2-4,6-7,9,12,24H,5,8,10H2,1H3,(H,21,25)(H,22,26)/b3-2-/t12-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human full-length Pim1 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser-112 preincubated fo... |
ACS Med Chem Lett 7: 408-12 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM192593
(US9187486, 65)Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1F |r| Show InChI InChI=1S/C22H23FN8/c1-14-9-15(24)13-30(12-14)20-6-8-25-11-19(20)28-22-27-10-16-4-5-18(29-31(16)22)21-17(23)3-2-7-26-21/h2-8,10-11,14-15H,9,12-13,24H2,1H3,(H,27,28)/t14-,15+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant Pim1 (unknown origin) by electrochemiluminescence assay |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM192586
(US9187486, 54)Show SMILES C[C@@H]1[C@@H](N)CCCN1c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C23H23F2N7/c1-14-18(26)6-3-11-31(14)21-9-10-27-13-20(21)29-23-28-12-15-7-8-19(30-32(15)23)22-16(24)4-2-5-17(22)25/h2,4-5,7-10,12-14,18H,3,6,11,26H2,1H3,(H,28,29)/t14-,18+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.0620 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant Pim1 (unknown origin) by electrochemiluminescence assay |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50174168
(CHEMBL3810121)Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(NC\C=C/C2)nc13 |r,c:24| Show InChI InChI=1S/C20H19N5O/c1-11-19-21-8-3-2-5-12-10-22-20(26)14-9-16(24-17(12)14)13-6-4-7-15(23-11)18(13)25-19/h2-4,6-7,9,12,24H,5,8,10H2,1H3,(H,21,25)(H,22,26)/b3-2-/t12-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.0700 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human full-length Pim2 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser 112 preincubated fo... |
ACS Med Chem Lett 7: 408-12 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM192539
(US9187486, 1)Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C22H21F2N7/c23-16-4-1-5-17(24)21(16)18-7-6-15-11-27-22(31(15)29-18)28-19-12-26-9-8-20(19)30-10-2-3-14(25)13-30/h1,4-9,11-12,14H,2-3,10,13,25H2,(H,27,28)/t14-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.0700 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant Pim1 (unknown origin) by electrochemiluminescence assay |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM238725
(US9394297, 406)Show SMILES CC(C)n1c(NC(C)(C)C)nc2c(cccc2c1=O)-c1cc2C(=O)N[C@H](C)c2[nH]1 Show InChI InChI=1S/C22H27N5O2/c1-11(2)27-20(29)14-9-7-8-13(18(14)25-21(27)26-22(4,5)6)16-10-15-17(24-16)12(3)23-19(15)28/h7-12,24H,1-6H3,(H,23,28)(H,25,26)/t12-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.0700 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ... |
J Med Chem 62: 1523-1540 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01733
BindingDB Entry DOI: 10.7270/Q25X2D97 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50174162
(CHEMBL3808669)Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(NCCCC2)nc13 |r| Show InChI InChI=1S/C20H21N5O/c1-11-19-21-8-3-2-5-12-10-22-20(26)14-9-16(24-17(12)14)13-6-4-7-15(23-11)18(13)25-19/h4,6-7,9,12,24H,2-3,5,8,10H2,1H3,(H,21,25)(H,22,26)/t12-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.0700 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human full-length Pim1 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser-112 preincubated fo... |
ACS Med Chem Lett 7: 408-12 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50517435
(CHEMBL4441708)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC(C)(C)C)n(CC1CC1)c2=O |r| Show InChI InChI=1S/C23H27N5O2/c1-12-18-16(20(29)24-12)10-17(25-18)14-6-5-7-15-19(14)26-22(27-23(2,3)4)28(21(15)30)11-13-8-9-13/h5-7,10,12-13,25H,8-9,11H2,1-4H3,(H,24,29)(H,26,27)/t12-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ... |
J Med Chem 62: 1523-1540 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01733
BindingDB Entry DOI: 10.7270/Q25X2D97 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50174149
(CHEMBL3808662)Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(NC\C(C)=C\C2)nc13 |r,t:25| Show InChI InChI=1S/C21H21N5O/c1-11-6-7-13-10-23-21(27)15-8-17(25-18(13)15)14-4-3-5-16-19(14)26-20(22-9-11)12(2)24-16/h3-6,8,13,25H,7,9-10H2,1-2H3,(H,22,26)(H,23,27)/b11-6+/t13-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human full-length Pim2 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser 112 preincubated fo... |
ACS Med Chem Lett 7: 408-12 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50517430
(CHEMBL4446411)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CC1)n(CC1(O)CC1)c2=O |r| Show InChI InChI=1S/C23H25N5O3/c1-12-17-15(19(29)24-12)10-16(25-17)13-4-3-5-14-18(13)26-21(27-22(2)6-7-22)28(20(14)30)11-23(31)8-9-23/h3-5,10,12,25,31H,6-9,11H2,1-2H3,(H,24,29)(H,26,27)/t12-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ... |
J Med Chem 62: 1523-1540 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01733
BindingDB Entry DOI: 10.7270/Q25X2D97 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50517435
(CHEMBL4441708)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC(C)(C)C)n(CC1CC1)c2=O |r| Show InChI InChI=1S/C23H27N5O2/c1-12-18-16(20(29)24-12)10-17(25-18)14-6-5-7-15-19(14)26-22(27-23(2,3)4)28(21(15)30)11-13-8-9-13/h5-7,10,12-13,25H,8-9,11H2,1-4H3,(H,24,29)(H,26,27)/t12-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ... |
J Med Chem 62: 1523-1540 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01733
BindingDB Entry DOI: 10.7270/Q25X2D97 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM238805
(US9394297, 492)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CC1)n(C1CC1)c2=O Show InChI InChI=1S/C22H23N5O2/c1-11-17-15(19(28)23-11)10-16(24-17)13-4-3-5-14-18(13)25-21(26-22(2)8-9-22)27(20(14)29)12-6-7-12/h3-5,10-12,24H,6-9H2,1-2H3,(H,23,28)(H,25,26)/t11-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ... |
J Med Chem 62: 1523-1540 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01733
BindingDB Entry DOI: 10.7270/Q25X2D97 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50200531
(CHEMBL3950251)Show SMILES N[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C22H22F2N8O/c23-13-2-1-3-14(24)20(13)17-5-4-12-8-28-22(32(12)30-17)29-18-9-27-7-6-19(18)31-10-15(25)21(33)16(26)11-31/h1-9,15-16,21,33H,10-11,25-26H2,(H,28,29)/t15-,16+,21+ | PDB
MMDB
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B.MOAD
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant Pim2 (unknown origin) by electrochemiluminescence assay |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM192574
(US9187486, 37 | US9187486, 39 | US9187486, 60)Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C23H23F2N7/c1-14-9-15(26)13-31(12-14)21-7-8-27-11-20(21)29-23-28-10-16-5-6-19(30-32(16)23)22-17(24)3-2-4-18(22)25/h2-8,10-11,14-15H,9,12-13,26H2,1H3,(H,28,29)/t14-,15+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.0940 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant Pim2 (unknown origin) by electrochemiluminescence assay |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50174133
(CHEMBL3810095)Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(N[C@H](C)CCC2)nc13 |r| Show InChI InChI=1S/C21H23N5O/c1-11-5-3-6-13-10-22-21(27)15-9-17(25-18(13)15)14-7-4-8-16-19(14)26-20(23-11)12(2)24-16/h4,7-9,11,13,25H,3,5-6,10H2,1-2H3,(H,22,27)(H,23,26)/t11-,13+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human full-length Pim1 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser-112 preincubated fo... |
ACS Med Chem Lett 7: 408-12 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50174149
(CHEMBL3808662)Show SMILES [H][C@]12CNC(=O)c3cc([nH]c13)-c1cccc3nc(C)c(NC\C(C)=C\C2)nc13 |r,t:25| Show InChI InChI=1S/C21H21N5O/c1-11-6-7-13-10-23-21(27)15-8-17(25-18(13)15)14-4-3-5-16-19(14)26-20(22-9-11)12(2)24-16/h3-6,8,13,25H,7,9-10H2,1-2H3,(H,22,26)(H,23,27)/b11-6+/t13-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human full-length Pim1 expressed in Escherichia coli assessed as phosphorylation of biotinylated BAD peptide at Ser-112 preincubated fo... |
ACS Med Chem Lett 7: 408-12 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00403
BindingDB Entry DOI: 10.7270/Q2MG7RD5 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM238637
(US9394297, 297)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1c(F)ccc2nc(C)c(NC(C)(C)C)nc12 Show InChI InChI=1S/C20H22FN5O/c1-9-16-11(19(27)23-9)8-14(24-16)15-12(21)6-7-13-17(15)25-18(10(2)22-13)26-20(3,4)5/h6-9,24H,1-5H3,(H,23,27)(H,25,26)/t9-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant Pim-2 (unknown origin) assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 resid... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM238805
(US9394297, 492)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CC1)n(C1CC1)c2=O Show InChI InChI=1S/C22H23N5O2/c1-11-17-15(19(28)23-11)10-16(24-17)13-4-3-5-14-18(13)25-21(26-22(2)8-9-22)27(20(14)29)12-6-7-12/h3-5,10-12,24H,6-9H2,1-2H3,(H,23,28)(H,25,26)/t11-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ... |
J Med Chem 62: 1523-1540 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01733
BindingDB Entry DOI: 10.7270/Q25X2D97 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM238707
(US9394297, 371)Show SMILES Cc1nc2ccc(F)c(-c3cc4c(cc[nH]c4=O)[nH]3)c2nc1NC(C)(C)C Show InChI InChI=1S/C20H20FN5O/c1-10-18(26-20(2,3)4)25-17-14(23-10)6-5-12(21)16(17)15-9-11-13(24-15)7-8-22-19(11)27/h5-9,24H,1-4H3,(H,22,27)(H,25,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant Pim-2 (unknown origin) assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 resid... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM238724
(US9394297, 405)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1c(F)ccc2c1nc(NC(C)(C)C)n(C)c2=O Show InChI InChI=1S/C20H22FN5O2/c1-9-15-11(17(27)22-9)8-13(23-15)14-12(21)7-6-10-16(14)24-19(25-20(2,3)4)26(5)18(10)28/h6-9,23H,1-5H3,(H,22,27)(H,24,25)/t9-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant Pim-1 (unknown origin) assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 resid... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM238637
(US9394297, 297)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1c(F)ccc2nc(C)c(NC(C)(C)C)nc12 Show InChI InChI=1S/C20H22FN5O/c1-9-16-11(19(27)23-9)8-14(24-16)15-12(21)6-7-13-17(15)25-18(10(2)22-13)26-20(3,4)5/h6-9,24H,1-5H3,(H,23,27)(H,25,26)/t9-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant Pim-1 (unknown origin) assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 resid... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM238724
(US9394297, 405)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1c(F)ccc2c1nc(NC(C)(C)C)n(C)c2=O Show InChI InChI=1S/C20H22FN5O2/c1-9-15-11(17(27)22-9)8-13(23-15)14-12(21)7-6-10-16(14)24-19(25-20(2,3)4)26(5)18(10)28/h6-9,23H,1-5H3,(H,22,27)(H,24,25)/t9-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant Pim-2 (unknown origin) assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 resid... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50517415
(CHEMBL4468122)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC(C)(C)C)n(CC1(N)CC1)c2=O |r| Show InChI InChI=1S/C23H28N6O2/c1-12-17-15(19(30)25-12)10-16(26-17)13-6-5-7-14-18(13)27-21(28-22(2,3)4)29(20(14)31)11-23(24)8-9-23/h5-7,10,12,26H,8-9,11,24H2,1-4H3,(H,25,30)(H,27,28)/t12-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ... |
J Med Chem 62: 1523-1540 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01733
BindingDB Entry DOI: 10.7270/Q25X2D97 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50517431
(CHEMBL4471849)Show SMILES CC(c1cn(C)cn1)n1c(NC2(C)CC2)nc2c(cccc2c1=O)-c1cc2C(=O)N[C@H](C)c2[nH]1 |r| Show InChI InChI=1S/C25H27N7O2/c1-13-20-17(22(33)27-13)10-18(28-20)15-6-5-7-16-21(15)29-24(30-25(3)8-9-25)32(23(16)34)14(2)19-11-31(4)12-26-19/h5-7,10-14,28H,8-9H2,1-4H3,(H,27,33)(H,29,30)/t13-,14?/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ... |
J Med Chem 62: 1523-1540 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01733
BindingDB Entry DOI: 10.7270/Q25X2D97 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM238788
(US9394297, 475)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC(C)(C)C)n(C1CC1)c2=O Show InChI InChI=1S/C22H25N5O2/c1-11-17-15(19(28)23-11)10-16(24-17)13-6-5-7-14-18(13)25-21(26-22(2,3)4)27(20(14)29)12-8-9-12/h5-7,10-12,24H,8-9H2,1-4H3,(H,23,28)(H,25,26)/t11-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ... |
J Med Chem 62: 1523-1540 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01733
BindingDB Entry DOI: 10.7270/Q25X2D97 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50517429
(CHEMBL4436404)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CC1)n(CC1CC1)c2=O |r| Show InChI InChI=1S/C23H25N5O2/c1-12-18-16(20(29)24-12)10-17(25-18)14-4-3-5-15-19(14)26-22(27-23(2)8-9-23)28(21(15)30)11-13-6-7-13/h3-5,10,12-13,25H,6-9,11H2,1-2H3,(H,24,29)(H,26,27)/t12-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ... |
J Med Chem 62: 1523-1540 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01733
BindingDB Entry DOI: 10.7270/Q25X2D97 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50517418
(CHEMBL4464030)Show SMILES CC(c1cn(C)cn1)n1c(NC(C)(C)C)nc2c(cccc2c1=O)-c1cc2C(=O)N[C@H](C)c2[nH]1 |r| Show InChI InChI=1S/C25H29N7O2/c1-13-20-17(22(33)27-13)10-18(28-20)15-8-7-9-16-21(15)29-24(30-25(3,4)5)32(23(16)34)14(2)19-11-31(6)12-26-19/h7-14,28H,1-6H3,(H,27,33)(H,29,30)/t13-,14?/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ... |
J Med Chem 62: 1523-1540 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01733
BindingDB Entry DOI: 10.7270/Q25X2D97 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50517421
(CHEMBL4461181)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC(C)(C)C)n(C[C@H]1CCCO1)c2=O |r| Show InChI InChI=1S/C24H29N5O3/c1-13-19-17(21(30)25-13)11-18(26-19)15-8-5-9-16-20(15)27-23(28-24(2,3)4)29(22(16)31)12-14-7-6-10-32-14/h5,8-9,11,13-14,26H,6-7,10,12H2,1-4H3,(H,25,30)(H,27,28)/t13-,14-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ... |
J Med Chem 62: 1523-1540 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01733
BindingDB Entry DOI: 10.7270/Q25X2D97 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM238725
(US9394297, 406)Show SMILES CC(C)n1c(NC(C)(C)C)nc2c(cccc2c1=O)-c1cc2C(=O)N[C@H](C)c2[nH]1 Show InChI InChI=1S/C22H27N5O2/c1-11(2)27-20(29)14-9-7-8-13(18(14)25-21(27)26-22(4,5)6)16-10-15-17(24-16)12(3)23-19(15)28/h7-12,24H,1-6H3,(H,23,28)(H,25,26)/t12-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ... |
J Med Chem 62: 1523-1540 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01733
BindingDB Entry DOI: 10.7270/Q25X2D97 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50517423
(CHEMBL4591512)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC(C)(C)C)n(CC1(O)CC1)c2=O |r| Show InChI InChI=1S/C23H27N5O3/c1-12-17-15(19(29)24-12)10-16(25-17)13-6-5-7-14-18(13)26-21(27-22(2,3)4)28(20(14)30)11-23(31)8-9-23/h5-7,10,12,25,31H,8-9,11H2,1-4H3,(H,24,29)(H,26,27)/t12-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ... |
J Med Chem 62: 1523-1540 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01733
BindingDB Entry DOI: 10.7270/Q25X2D97 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM50517434
(CHEMBL4470271)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CC1)n(C1CCC1)c2=O |r| Show InChI InChI=1S/C23H25N5O2/c1-12-18-16(20(29)24-12)11-17(25-18)14-7-4-8-15-19(14)26-22(27-23(2)9-10-23)28(21(15)30)13-5-3-6-13/h4,7-8,11-13,25H,3,5-6,9-10H2,1-2H3,(H,24,29)(H,26,27)/t12-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.140 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ... |
J Med Chem 62: 1523-1540 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01733
BindingDB Entry DOI: 10.7270/Q25X2D97 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM50517433
(CHEMBL4450494)Show SMILES C[C@@H](c1cn(C)cn1)n1c(NC2(C)CC2)nc2c(cccc2c1=O)-c1cc2C(=O)N[C@H](C)c2[nH]1 |r| Show InChI InChI=1S/C25H27N7O2/c1-13-20-17(22(33)27-13)10-18(28-20)15-6-5-7-16-21(15)29-24(30-25(3)8-9-25)32(23(16)34)14(2)19-11-31(4)12-26-19/h5-7,10-14,28H,8-9H2,1-4H3,(H,27,33)(H,29,30)/t13-,14+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins ... |
J Med Chem 62: 1523-1540 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01733
BindingDB Entry DOI: 10.7270/Q25X2D97 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM192645
(US9187486, 96)Show SMILES C[C@@H]1CC[C@H](N)CN1c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1F |r| Show InChI InChI=1S/C22H23FN8/c1-14-4-5-15(24)13-30(14)20-8-10-25-12-19(20)28-22-27-11-16-6-7-18(29-31(16)22)21-17(23)3-2-9-26-21/h2-3,6-12,14-15H,4-5,13,24H2,1H3,(H,27,28)/t14-,15+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant Pim1 (unknown origin) by electrochemiluminescence assay |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
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