| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 14 |
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| Ligand | BDBM50326908 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_663241 (CHEMBL1251348) |
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| IC50 | 78±n/a nM |
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| Citation |  Wu, B; Wang, HL; Pettus, L; Wurz, RP; Doherty, EM; Henkle, B; McBride, HJ; Saris, CJ; Wong, LM; Plant, MH; Sherman, L; Lee, MR; Hsieh, F; Tasker, AS Discovery of pyridazinopyridinones as potent and selective p38 mitogen-activated protein kinase inhibitors. J Med Chem53:6398-411 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 14 |
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| Name: | Mitogen-activated protein kinase 14 |
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| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 41286.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16539 |
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| Residue: | 360 |
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| Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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| BDBM50326908 |
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| n/a |
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| Name | BDBM50326908 |
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| Synonyms: | 8-(2,4-Difluorophenyl)-3-(4-fluorophenoxy)-1-methylpyrido-[3,2-d]pyridazin-2(1H)-one | CHEMBL1253980 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H12F3N3O2 |
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| Mol. Mass. | 383.3234 |
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| SMILES | Cn1c2c(nncc2cc(Oc2ccc(F)cc2)c1=O)-c1ccc(F)cc1F |
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| Structure | 
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