| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase B |
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| Ligand | BDBM50328437 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_665546 (CHEMBL1261377) |
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| IC50 | 10540±n/a nM |
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| Citation |  Bouloc, N; Large, JM; Kosmopoulou, M; Sun, C; Faisal, A; Matteucci, M; Reynisson, J; Brown, N; Atrash, B; Blagg, J; McDonald, E; Linardopoulos, S; Bayliss, R; Bavetsias, V Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells. Bioorg Med Chem Lett20:5988-93 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aurora kinase B |
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| Name: | Aurora kinase B |
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| Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
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| Type: | Protein |
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| Mol. Mass.: | 39327.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96GD4 |
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| Residue: | 344 |
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| Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
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| BDBM50328437 |
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| n/a |
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| Name | BDBM50328437 |
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| Synonyms: | CHEMBL1230687 | N-(3-(3-chloro-8-(4-morpholinophenylamino)imidazo[1,2-a]pyrazin-6-yl)benzyl)methanesulfonamide | N-(3-{3-chloro-8-[(4-morpholin-4-ylphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}benzyl)methanesulfonamide |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25ClN6O3S |
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| Mol. Mass. | 513.012 |
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| SMILES | CS(=O)(=O)NCc1cccc(c1)-c1cn2c(Cl)cnc2c(Nc2ccc(cc2)N2CCOCC2)n1 |
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| Structure | 
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