| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aurora kinase A |
|---|
| Ligand | BDBM50328428 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_665540 (CHEMBL1261371) |
|---|
| IC50 | 7310±n/a nM |
|---|
| Citation |  Bouloc, N; Large, JM; Kosmopoulou, M; Sun, C; Faisal, A; Matteucci, M; Reynisson, J; Brown, N; Atrash, B; Blagg, J; McDonald, E; Linardopoulos, S; Bayliss, R; Bavetsias, V Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells. Bioorg Med Chem Lett20:5988-93 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aurora kinase A |
|---|
| Name: | Aurora kinase A |
|---|
| Synonyms: | AIK | AIRK1 | ARK-1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK15 GN | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | Serine/threonine-protein kinase aurora-A | Synonyms=AIK | aurora-2 | hARK1 |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 45830.98 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O14965 |
|---|
| Residue: | 403 |
|---|
| Sequence: | MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
|
|
|
|---|
| BDBM50328428 |
|---|
| n/a |
|---|
| Name | BDBM50328428 |
|---|
| Synonyms: | 2-methoxy-N-(3-(8-(4-methoxyphenylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)acetamide | CHEMBL1258151 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H21N5O3 |
|---|
| Mol. Mass. | 403.4338 |
|---|
| SMILES | COCC(=O)Nc1cccc(c1)-c1cn2ccnc2c(Nc2ccc(OC)cc2)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
