| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50328948 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_673999 (CHEMBL1275176) |
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| Ki | 3280±n/a nM |
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| Citation |  Santillan, A; McClure, KJ; Allison, BD; Lord, B; Boggs, JD; Morton, KL; Everson, AM; Nepomuceno, D; Letavic, MA; Lee-Dutra, A; Lovenberg, TW; Carruthers, NI; Grice, CA Indole- and benzothiophene-based histamine H3 antagonists. Bioorg Med Chem Lett20:6226-30 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48691.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
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| Residue: | 445 |
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| Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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| BDBM50328948 |
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| n/a |
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| Name | BDBM50328948 |
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| Synonyms: | (4-isopropylpiperazin-1-yl)(3-(piperidine-1-carbonyl)benzo[b]thiophen-5-yl)methanone | CHEMBL1270172 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H29N3O2S |
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| Mol. Mass. | 399.55 |
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| SMILES | CC(C)N1CCN(CC1)C(=O)c1ccc2scc(C(=O)N3CCCCC3)c2c1 |
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| Structure | 
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