Reaction Details |
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Target | Renin |
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Ligand | BDBM50329027 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_674153 (CHEMBL1274250) |
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IC50 | 9350±n/a nM |
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Citation | Scheiper, B; Matter, H; Steinhagen, H; Stilz, U; Böcskei, Z; Fleury, V; McCort, G Discovery and optimization of a new class of potent and non-chiral indole-3-carboxamide-based renin inhibitors. Bioorg Med Chem Lett20:6268-72 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Renin |
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Name: | Renin |
Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 45058.99 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 406 |
Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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BDBM50329027 |
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n/a |
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Name | BDBM50329027 |
Synonyms: | (2-(3-fluoro-2-methylbenzyl)-1-(6-hydroxypyridin-3-yl)-1H-indol-3-yl)(piperazin-1-yl)methanone | CHEMBL1271286 |
Type | Small organic molecule |
Emp. Form. | C26H25FN4O2 |
Mol. Mass. | 444.5007 |
SMILES | Cc1c(F)cccc1Cc1c(C(=O)N2CCNCC2)c2ccccc2n1-c1ccc(=O)[nH]c1 |
Structure |
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