| Reaction Details |
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 | Report a problem with these data |
| Target | Lysosomal acid glucosylceramidase |
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| Ligand | BDBM50329781 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_674763 (CHEMBL1274071) |
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| Ki | 32000±n/a nM |
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| Citation |  Aguilar-Moncayo, M; García-Moreno, MI; Stütz, AE; García Fernández, JM; Wrodnigg, TM; Ortiz Mellet, C Fluorescent-tagged sp2-iminosugars with potentß-glucosidase inhibitory activity. Bioorg Med Chem18:7439-45 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysosomal acid glucosylceramidase |
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| Name: | Lysosomal acid glucosylceramidase |
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| Synonyms: | Acid beta-glucosidase | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_BOVIN | Glucosylceramidase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59862.93 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_1460504 |
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| Residue: | 536 |
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| Sequence: | MELSSPSREEYPMPRGRVGIMAASLMGLLLLHTVSWVSGARPCSPKSFGYSSVVCVCNGT
YCDSLDPLTLPDPGTFSRFESTRSGRRMELSLGTIQANRTGTGLLLTLQPDQKFQKVKGF
GGAMTDAAALNILALSPAARNLLLKSYFSEEGIEYNIIRVPMASCDFSIRTYTYDDSPDD
FQLLNFSLPEEDVKLKIPLIHQALELANRSVSLFASPWTSPTWLKTNGAVNGKGTLKGQA
GDLYHKTWARYFVKFLDAYAEHKLRFWAVTAENEPTAGLLTGYPFQCLGFTPEHQRDFIA
RDLGPILANSTHRDVRLLMLDDQRLLLPRWAQVVLADPEAAKYVHGIAVHWYLDFLAPAK
ATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMRYSHSIITNLLYHVVGWTDW
NLALNPEGGPNWVRNFVDSPIIVDIAKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASKK
SDLDTVALLRPDGSAVAVVLNRSSKDVPLTIKDPAVGFMETVSPGYSIHTYLWRRQ
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| BDBM50329781 |
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| n/a |
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| Name | BDBM50329781 |
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| Synonyms: | 5-N,6-S-[N'-[4-(7'-Diethylaminocoumarin-30-ylcarboxamido)butyl]iminomethylidene]-6-thionojirimycin | CHEMBL1272019 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H34N4O8S2 |
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| Mol. Mass. | 570.679 |
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| SMILES | CCN(CC)c1ccc2cc(c(=O)oc2c1)S(=O)(=O)NCCCC\N=C1/SC[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O)N12 |r| |
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| Structure | 
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