| Reaction Details |
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 | Report a problem with these data |
| Target | Melanin-concentrating hormone receptor 1 |
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| Ligand | BDBM50209704 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_675953 (CHEMBL1272819) |
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| Ki | 314±n/a nM |
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| Citation |  Cirauqui, N; Schrey, AK; Galiano, S; Ceras, J; Pérez-Silanes, S; Aldana, I; Monge, A; Kühne, R Building a MCHR1 homology model provides insight into the receptor-antagonist contacts that are important for the development of new anti-obesity agents. Bioorg Med Chem18:7365-79 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanin-concentrating hormone receptor 1 |
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| Name: | Melanin-concentrating hormone receptor 1 |
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| Synonyms: | G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 45976.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays. |
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| Residue: | 422 |
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| Sequence: | MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARL
WEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTIC
LLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHF
GETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALS
FISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRI
LQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVY
LYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESK
GT
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| BDBM50209704 |
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| n/a |
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| Name | BDBM50209704 |
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| Synonyms: | 1-(4'-fluoro-4-biphenylmethyl)-3-isopropyl-1-{2-[1-(4-methylbenzyl)-4-piperidinyl]ethyl}urea | CHEMBL239904 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H40FN3O |
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| Mol. Mass. | 501.6779 |
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| SMILES | CC(C)NC(=O)N(CCC1CCN(Cc2ccc(C)cc2)CC1)Cc1ccc(cc1)-c1ccc(F)cc1 |
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| Structure | 
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