Reaction Details |
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Target | Bcl-2-related protein A1 |
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Ligand | BDBM50330258 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_676277 (CHEMBL1273518) |
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Ki | 470±n/a nM |
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Citation | Wei, J; Kitada, S; Stebbins, JL; Placzek, W; Zhai, D; Wu, B; Rega, MF; Zhang, Z; Cellitti, J; Yang, L; Dahl, R; Reed, JC; Pellecchia, M Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. J Med Chem53:8000-11 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Bcl-2-related protein A1 |
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Name: | Bcl-2-related protein A1 |
Synonyms: | B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS |
Type: | Apoptosis regulator protein |
Mol. Mass.: | 20130.01 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 175 |
Sequence: | MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVN
VVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISY
FVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
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BDBM50330258 |
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n/a |
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Name | BDBM50330258 |
Synonyms: | 6,6',7,7'-Tetrahydroxy-3,3'-dimethyl-1,1',4,4'-tetraoxo-N5,N5'-bis(2-phenylpropyl)-1,1',4,4'-tetrahydro-2,2'-binaphthyl-5,5'-dicarboxamide | CHEMBL1269070 |
Type | Small organic molecule |
Emp. Form. | C42H36N2O10 |
Mol. Mass. | 728.7426 |
SMILES | CC(CNC(=O)c1c(O)c(O)cc2C(=O)C(=C(C)C(=O)c12)C1=C(C)C(=O)c2c(cc(O)c(O)c2C(=O)NCC(C)c2ccccc2)C1=O)c1ccccc1 |c:23,t:15| |
Structure |
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