Reaction Details | |||
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Target | Bcl-2-like protein 1 | ||
Ligand | BDBM50330252 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_676275 (CHEMBL1273516) | ||
IC50 | 2990±n/a nM | ||
Citation | Wei, J; Kitada, S; Stebbins, JL; Placzek, W; Zhai, D; Wu, B; Rega, MF; Zhang, Z; Cellitti, J; Yang, L; Dahl, R; Reed, JC; Pellecchia, M Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. J Med Chem53:8000-11 (2010) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Bcl-2-like protein 1 | |||
Name: | Bcl-2-like protein 1 | ||
Synonyms: | Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD) | ||
Type: | Mitochondrion membrane; Single-pass membrane protein | ||
Mol. Mass.: | 26039.60 | ||
Organism: | Homo sapiens (Human) | ||
Description: | n/a | ||
Residue: | 233 | ||
Sequence: |
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BDBM50330252 | |||
n/a | |||
Name | BDBM50330252 | ||
Synonyms: | 5,5'-Bis(cyclopentylmethyl)-6,6',7,7'-tetrahydroxy-3,3'-dimethyl-2,2'-binaphthyl-1,1',4,4'-tetraone | CHEMBL1269073 | ||
Type | Small organic molecule | ||
Emp. Form. | C34H34O8 | ||
Mol. Mass. | 570.629 | ||
SMILES | Oc1cc2c(O)c(-c3c(O)c4cc(O)c(O)c(=CC5CCCC5)c4c(O)c3=C)c(=C)c(O)c2c(=CC2CCCC2)c1O |w:34.38,17.17,(-10.24,1.31,;-8.91,.55,;-7.57,1.33,;-6.23,.55,;-4.9,1.33,;-4.9,2.87,;-3.55,.55,;-2.22,1.32,;-.89,.54,;-.89,-1,;.44,1.3,;1.76,.52,;3.11,1.27,;4.43,.49,;3.12,2.82,;4.47,3.58,;1.79,3.61,;1.8,5.15,;3.14,5.91,;4.38,5,;5.63,5.9,;5.16,7.36,;3.62,7.37,;.45,2.85,;-.88,3.62,;-.88,5.16,;-2.22,2.85,;-3.56,3.62,;-3.55,-1,;-2.22,-1.77,;-4.89,-1.77,;-4.89,-3.31,;-6.23,-1,;-7.57,-1.77,;-7.57,-3.31,;-8.91,-4.08,;-10.18,-3.19,;-11.41,-4.12,;-10.91,-5.57,;-9.37,-5.55,;-8.91,-1,;-10.24,-1.77,)| | ||
Structure |