| Reaction Details |
|---|
 | Report a problem with these data |
| Target | DNA gyrase subunit B |
|---|
| Ligand | BDBM50330301 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_677263 (CHEMBL1279101) |
|---|
| IC50 | 276±n/a nM |
|---|
| Citation |  Anderle, C; Stieger, M; Burrell, M; Reinelt, S; Maxwell, A; Page, M; Heide, L Biological activities of novel gyrase inhibitors of the aminocoumarin class. Antimicrob Agents Chemother52:1982-90 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| DNA gyrase subunit B |
|---|
| Name: | DNA gyrase subunit B |
|---|
| Synonyms: | DNA gyrase subunit B | DNA gyrase subunit B (gyrB) | GYRB_ECOLI | Type IIA topoisomerase subunit GyrB | acrB | cou | gyrB | himB | hisU | nalC | parA | pcbA |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 89941.28 |
|---|
| Organism: | Escherichia coli (strain K12) |
|---|
| Description: | P0AES6 |
|---|
| Residue: | 804 |
|---|
| Sequence: | MSNSYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEII
VTIHADNSVSVQDDGRGIPTGIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGV
SVVNALSQKLELVIQREGKIHRQIYEHGVPQAPLAVTGETEKTGTMVRFWPSLETFTNVT
EFEYEILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHYEGGIKAFVEYLNKNKTPIHPNI
FYFSTEKDGIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLAGFRAAMTRTLNAYMDKE
GYSKKAKVSATGDDAREGLIAVVSVKVPDPKFSSQTKDKLVSSEVKSAVEQQMNELLAEY
LLENPTDAKIVVGKIIDAARAREAARRAREMTRRKGALDLAGLPGKLADCQERDPALSEL
YLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIGR
DEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIVERGHVYIAQPPLYKVKKG
KQEQYIKDDEAMDQYQISIALDGATLHTNASAPALAGEALEKLVSEYNATQKMINRMERR
YPKAMLKELIYQPTLTEADLSDEQTVTRWVNALVSELNDKEQHGSQWKFDVHTNAEQNLF
EPIVRVRTHGVDTDYPLDHEFITGGEYRRICTLGEKLRGLLEEDAFIERGERRQPVASFE
QALDWLVKESRRGLSIQRYKGLGEMNPEQLWETTMDPESRRMLRVTVKDAIAADQLFTTL
MGDAVEPRRAFIEENALKAANIDI
|
|
|
|---|
| BDBM50330301 |
|---|
| n/a |
|---|
| Name | BDBM50330301 |
|---|
| Synonyms: | (3R,4S,5R,6R)-6-(3-((E)-3-(3-chloro-4-hydroxyphenyl)acrylamido)-4-hydroxy-2-oxo-2H-chromen-7-yloxy)-5-hydroxy-3-methoxy-2,2-dimethyltetrahydro-2H-pyran-4-yl 5-methyl-1H-pyrrole-2-carboxylate | CHEMBL1275892 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C32H31ClN2O11 |
|---|
| Mol. Mass. | 655.048 |
|---|
| SMILES | CO[C@@H]1[C@@H](OC(=O)c2ccc(C)[nH]2)[C@@H](O)[C@H](Oc2ccc3c(O)c(NC(=O)\C=C\c4ccc(O)c(Cl)c4)c(=O)oc3c2)OC1(C)C |r| |
|---|
| Structure | 
|
|---|
Search and Browse
