| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50330357 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_685578 (CHEMBL1285356) |
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| IC50 | 20±n/a nM |
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| Citation |  Webb, RL; Schiering, N; Sedrani, R; Maibaum, J Direct renin inhibitors as a new therapy for hypertension. J Med Chem53:7490-520 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50330357 |
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| n/a |
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| Name | BDBM50330357 |
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| Synonyms: | CHEMBL1276270 | tert-butyl(6S,9S,12S)-9-((1H-imidazol-5-yl)methyl)-6-(((S)-1-(butylamino)-3-methyl-1-oxobutan-2-ylamino)methyl)-8,11-dioxo-2,3,4,5,6,7,8,9,10,11,12,13-dodecahydrobenzo[b][1,7,10]oxadiazacyclopentadecin-12-ylcarbamate |
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| Type | Small organic molecule |
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| Emp. Form. | C35H55N7O6 |
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| Mol. Mass. | 669.8545 |
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| SMILES | CCCCNC(=O)[C@@H](NC[C@@H]1CCCCOc2ccccc2C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C |r| |
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| Structure | 
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