Reaction Details |
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Target | Renin |
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Ligand | BDBM50330362 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_685576 (CHEMBL1285354) |
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IC50 | 18±n/a nM |
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Citation | Webb, RL; Schiering, N; Sedrani, R; Maibaum, J Direct renin inhibitors as a new therapy for hypertension. J Med Chem53:7490-520 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Renin |
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Name: | Renin |
Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 45058.99 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 406 |
Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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BDBM50330362 |
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n/a |
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Name | BDBM50330362 |
Synonyms: | (1R,5S)-N-cyclopropyl-N-((2-methoxy-3-methylpyridin-4-yl)methyl)-7-(4-(3-(2-methoxybenzyloxy)propoxy)phenyl)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxamide | CHEMBL1276274 |
Type | Small organic molecule |
Emp. Form. | C36H44N4O5 |
Mol. Mass. | 612.7584 |
SMILES | COc1ccccc1COCCCOc1ccc(cc1)C1=C([C@H]2CNC[C@@H](C1)N2)C(=O)N(Cc1ccnc(OC)c1C)C1CC1 |r,t:22| |
Structure |
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