| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histamine H1 receptor |
|---|
| Ligand | BDBM50330749 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_685211 (CHEMBL1287099) |
|---|
| Ki | 14.13±n/a nM |
|---|
| Citation |  Gianotti, M; Botta, M; Brough, S; Carletti, R; Castiglioni, E; Corti, C; Dal-Cin, M; Delle Fratte, S; Korajac, D; Lovric, M; Merlo, G; Mesic, M; Pavone, F; Piccoli, L; Rast, S; Roscic, M; Sava, A; Smehil, M; Stasi, L; Togninelli, A; Wigglesworth, MJ Novel spirotetracyclic zwitterionic dual H(1)/5-HT(2A) receptor antagonists for the treatment of sleep disorders. J Med Chem53:7778-95 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histamine H1 receptor |
|---|
| Name: | Histamine H1 receptor |
|---|
| Synonyms: | HISTAMINE H1 | HRH1_RAT | Hrh1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 55716.35 |
|---|
| Organism: | RAT |
|---|
| Description: | HISTAMINE H1 HRH1 RAT::P31390 |
|---|
| Residue: | 486 |
|---|
| Sequence: | MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLRYRTKTRASATILGAWFFSFLWVIPILGWHHFMPPAPELREDKC
ETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPSFSELKLR
SDDTKEGAKKPGRESPWGVLKRPSRDPSVGLDQKSTSEDPKMTSPTVFSQEGERETRPCF
RLDIMQKQSVAEGDVRGSKANDQALSQPKMDEQSLNTCRRISETSEDQTLVDQQSFSRTT
DSDTSIEPGPGRVKSRSGSNSGLDYIKITWKRLRSHSRQYVSGLHLNRERKAAKQLGFIM
AAFILCWIPYFIFFMVIAFCKSCCSEPMHMFTIWLGYINSTLNPLIYPLCNENFKKTFKK
ILHIRS
|
|
|
|---|
| BDBM50330749 |
|---|
| n/a |
|---|
| Name | BDBM50330749 |
|---|
| Synonyms: | 1-(11'H-Spiro[cyclopentane-1,10'-dibenzo[b,f]oxepin]-3-yl)-3-azetidinecarboxylic Acid | CHEMBL1277312 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H23NO3 |
|---|
| Mol. Mass. | 349.4229 |
|---|
| SMILES | OC(=O)C1CN(C1)C1CCC2(C1)Cc1ccccc1Oc1ccccc21 |
|---|
| Structure | 
|
|---|
Search and Browse
