Reaction Details |
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Target | Cytochrome P450 2B6 |
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Ligand | BDBM50184924 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_686354 (CHEMBL1293110) |
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IC50 | >10000000±n/a nM |
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Citation | Hadden, M; Deering, DM; Henderson, AJ; Surman, MD; Luche, M; Khmelnitsky, Y; Vickers, S; Viggers, J; Cheetham, S; Guzzo, PR Synthesis and SAR of 4-aryl-1-(indazol-5-yl)pyridin-2(1H)ones as MCH-1 antagonists for the treatment of obesity. Bioorg Med Chem Lett20:7020-3 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 2B6 |
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Name: | Cytochrome P450 2B6 |
Synonyms: | CP2B6_HUMAN | CYP2B6 | Cytochrome P450 2B6 (CYP2B6) |
Type: | Protein |
Mol. Mass.: | 56289.75 |
Organism: | Homo sapiens (Human) |
Description: | P20813 |
Residue: | 491 |
Sequence: | MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE
KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR
WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIIC
SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE
INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT
ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS
DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL
KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI
PPTYQIRFLPR
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BDBM50184924 |
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n/a |
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Name | BDBM50184924 |
Synonyms: | 1-((1S,2R,5S)-5-(4-cyanophenyl)bicyclo[3.1.0]hexan-2-yl)-3-(4-fluoro-3-(trifluoromethyl)phenyl)-1-(3-(4-methylpiperazin-1-yl)propyl)urea | CHEMBL205285 | N-[trans-5-(4-cyanophenyl)bicyclo[3.1.0]hex-2-yl]-N'-[4-fluoro-3-(trifluoromethyl)phenyl)-N-[3-(4-methyl-1-piperazinyl)propyl]-urea |
Type | Small organic molecule |
Emp. Form. | C29H33F4N5O |
Mol. Mass. | 543.5988 |
SMILES | CN1CCN(CCCN([C@@H]2CC[C@@]3(C[C@H]23)c2ccc(cc2)C#N)C(=O)Nc2ccc(F)c(c2)C(F)(F)F)CC1 |
Structure |
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