Ki Summary

Reaction Details

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Target

Potassium voltage-gated channel subfamily A member 3

Ligand

BDBM50331502

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_687187 (CHEMBL1291812)

IC50

3080±n/a nM

Citation

Haffner, CD; Thomson, SA; Guo, Y; Petrov, K; Larkin, A; Banker, P; Schaaf, G; Dickerson, S; Gobel, J; Gillie, D; Condreay, JP; Poole, C; Carpenter, T; Ulrich, J Substituted N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs as potent Kv1.3 ion channel blockers. Part 2. Bioorg Med Chem Lett20:6989-92 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Potassium voltage-gated channel subfamily A member 3

Name:

Potassium voltage-gated channel subfamily A member 3

Synonyms:

Type:

PROTEIN

Mol. Mass.:

63835.47

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1513935

Residue:

575

Sequence:

MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDH
LLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLK
TLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIF
SEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVS
VLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVET
LCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSL
AILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE
ADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIV
SNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHS
AFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV

BDBM50331502

n/a

Name

BDBM50331502

Synonyms:

1-{3-[(6-Fluoro-1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-pheny l-amino]-2,2-dimethyl-propyl}-3-methyl-urea | CHEMBL1290738

Type

Small organic molecule

Emp. Form.

C20H23FN4O3S

Mol. Mass.

418.485

SMILES

CNC(=O)NCC(C)(C)CN(C1=NS(=O)(=O)c2cc(F)ccc12)c1ccccc1 |t:11|

Structure