| Reaction Details |
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 | Report a problem with these data |
| Target | Transporter |
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| Ligand | BDBM50331524 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_687286 (CHEMBL1291962) |
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| Ki | 580±n/a nM |
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| Citation |  Gu, X; Izenwasser, S; Wade, D; Housman, A; Gulasey, G; Rhoden, JB; Savoie, CD; Mobley, DL; Lomenzo, SA; Trudell, ML Synthesis and structure-activity studies of benzyl ester meperidine and normeperidine derivatives as selective serotonin transporter ligands. Bioorg Med Chem18:8356-64 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transporter |
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| Name: | Transporter |
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| Synonyms: | NE transporter | NET | Norepinephrine transporter(NET) |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 69236.90 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Q63380 |
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| Residue: | 617 |
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| Sequence: | MLLARMKPQVQPELGGADQLPEQPLRPCKTADLLVVKERNGVQCLLASQDGDAQPRETWG
KEIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQFN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHAW
NSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFA
IFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFLMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAYGITPENEHHL
VAQRDVRQFQLRHWLAI
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| BDBM50331524 |
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| n/a |
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| Name | BDBM50331524 |
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| Synonyms: | 4-Bromobenzyl 4-(3,4-dichlorophenyl)-1-methylpiperidine-4-carboxylate hydrochloride | CHEMBL1289302 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H20BrCl2NO2 |
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| Mol. Mass. | 457.188 |
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| SMILES | CN1CCC(CC1)(C(=O)OCc1ccc(Br)cc1)c1ccc(Cl)c(Cl)c1 |
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| Structure | 
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