| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prostaglandin D2 receptor |
|---|
| Ligand | BDBM50331743 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_687945 (CHEMBL1291617) |
|---|
| Ki | 0.39±n/a nM |
|---|
| Citation |  Li, L; Beaulieu, C; Carriere, MC; Denis, D; Greig, G; Guay, D; O'Neill, G; Zamboni, R; Wang, Z Potent and highly selective DP1 antagonists with 2,3,4,9-tetrahydro-1H-carbazole as pharmacophore. Bioorg Med Chem Lett20:7462-5 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prostaglandin D2 receptor |
|---|
| Name: | Prostaglandin D2 receptor |
|---|
| Synonyms: | PD2R_HUMAN | PTGDR | Prostaglandin D2 | Prostaglandin D2 receptor | Prostanoid DP receptor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 40288.87 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q13258 |
|---|
| Residue: | 359 |
|---|
| Sequence: | MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSV
FYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSST
LQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPG
TWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCT
RDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTS
EEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL
|
|
|
|---|
| BDBM50331743 |
|---|
| n/a |
|---|
| Name | BDBM50331743 |
|---|
| Synonyms: | 2-((R)-9-((R)-1-(4-chlorophenyl)-2,2-difluoroethyl)-6-fluoro-8-(methylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-1-yl)acetic acid | CHEMBL1290755 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H21ClF3NO4S |
|---|
| Mol. Mass. | 499.93 |
|---|
| SMILES | CS(=O)(=O)c1cc(F)cc2c3CCC[C@H](CC(O)=O)c3n([C@@H](C(F)F)c3ccc(Cl)cc3)c12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
