| Reaction Details |
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 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
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| Ligand | BDBM50331753 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_686691 (CHEMBL1290871) |
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| IC50 | 210±n/a nM |
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| Citation |  Lu, Z; Napolitano, JB; Theberge, A; Ali, A; Hammond, ML; Tan, E; Tong, X; Xu, SS; Latham, MJ; Peterson, LB; Anderson, MS; Eveland, SS; Guo, Q; Hyland, SA; Milot, DP; Chen, Y; Sparrow, CP; Wright, SD; Sinclair, PJ Design of a novel class of biphenyl CETP inhibitors. Bioorg Med Chem Lett20:7469-72 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholesteryl ester transfer protein |
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| Name: | Cholesteryl ester transfer protein |
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| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
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| Type: | Enzyme |
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| Mol. Mass.: | 54751.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11597 |
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| Residue: | 493 |
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| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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| BDBM50331753 |
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| n/a |
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| Name | BDBM50331753 |
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| Synonyms: | CHEMBL1290190 | methyl 3,5-bis(trifluoromethyl)benzyl((5'-ethyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl)methyl)carbamate |
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| Type | Small organic molecule |
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| Emp. Form. | C28H24F9NO3 |
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| Mol. Mass. | 593.4807 |
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| SMILES | CCc1ccc(OC)c(c1)-c1ccc(cc1CN(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(=O)OC)C(F)(F)F |
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| Structure | 
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