| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 2 |
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| Ligand | BDBM50331890 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_687200 (CHEMBL1291825) |
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| IC50 | 180±n/a nM |
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| Citation |  Lai, Y; Ma, L; Huang, W; Yu, X; Zhang, Y; Ji, H; Tian, J Synthesis and biological evaluation of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors. Bioorg Med Chem Lett20:7349-53 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin G/H synthase 2 |
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| Name: | Prostaglandin G/H synthase 2 |
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| Synonyms: | COX-2 | COX2 | PGH synthase 2 | PGH2_RABIT | PGHS-2 | PHS II | PTGS2 | Prostaglandin H2 synthase 2 | Prostaglandin-endoperoxide synthase 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 69015.55 |
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| Organism: | Oryctolagus cuniculus |
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| Description: | ChEMBL_687200 |
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| Residue: | 604 |
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| Sequence: | MLARALLLCAAVALSHAANPCCSNPCQNRGVCMTMGFDQYKCDCTRTGFYGENCSTPEFL
TRIKLLLKPTPDTVHYILTHFKGVWNIVNSIPFLRNSIMKYVLTSRSHMIDSPPTYNVHY
NYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGKKELPDSKDVVEKLLLRRKFIPDPQGT
NMMFAFFAQHFTHQFFKTDLKRGPAFTKGLGHGVDLNHIYGETLDRQHKLRLFKDGKMKY
QVIDGEVYPPTVKDTQVEMIYPPHIPAHLQFAVGQEVFGLVPGLMMYATIWLREHNRVCD
VLKQEHPEWDDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQ
NRIAAEFNTLYHWHPLLPDTFQIDDQQYNYQQFLYNNSILLEHGLTQFVESFTRQIAGRV
AGGRNVPPAVQKVAKASIDQSRQMKYQSLNEYRKRFLLKPYESFEELTGEKEMAAELEAL
YGDIDAVELYPALLVERPRPDAIFGESMVEMGAPFSLKGLMGNPICSPNYWKPSTFGGEV
GFKIVNTASIQSLICNNVKGCPFTSFNVPDPQLTKTVTINASASHSRLEDINPTVLLKGR
STEL
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| BDBM50331890 |
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| n/a |
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| Name | BDBM50331890 |
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| Synonyms: | CHEMBL1290661 | E-5-Fluoro-3-[[4-(sulfamoyl)phenyl]methylene]-indolin-2-one |
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| Type | Small organic molecule |
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| Emp. Form. | C15H11FN2O3S |
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| Mol. Mass. | 318.323 |
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| SMILES | NS(=O)(=O)c1ccc(\C=C2\C(=O)Nc3ccc(F)cc23)cc1 |
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| Structure | 
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