Reaction Details |
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Target | Prostaglandin G/H synthase 1 |
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Ligand | BDBM50331888 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_687201 (CHEMBL1291826) |
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IC50 | 2560±n/a nM |
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Citation | Lai, Y; Ma, L; Huang, W; Yu, X; Zhang, Y; Ji, H; Tian, J Synthesis and biological evaluation of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors. Bioorg Med Chem Lett20:7349-53 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Prostaglandin G/H synthase 1 |
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Name: | Prostaglandin G/H synthase 1 |
Synonyms: | COX1 | Cyclooxygenase-1 | PGH1_RABIT | PTGS1 |
Type: | PROTEIN |
Mol. Mass.: | 69079.81 |
Organism: | Oryctolagus cuniculus |
Description: | ChEMBL_687201 |
Residue: | 606 |
Sequence: | MSRSSPSLRLPVLLLLLLLLLLPPPPPVLPADPGAPAPVNPCCYFPCQHQGVCVRVALDR
YQCDCTRTGYSGPNCTVPDLWTWLRSSLRPSPTFVHYLLTHVRWFWEFVNATFIRDTLMR
LVLTVRSNLIPSPPTYNLDYDYISWEAFSNVSYYTRVLPSVPKDCPTPMGTKGKKQLPDA
QVLAHRFLLRRTFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIY
GDSLERQYHLRLFKDGKLKYQVLDGEVYPPSVEEAPVLMHYPRGVPPRSQMAVGQEVFGL
LPGLMLYATLWLREHNRVCDLLKAEHPTWDDEQLFQTTRLILIGETIKIVIEEYVQQLSG
YFLQLKFDPEMLFSVQFQYRNRIAMEFNHLYHWHPLMPDSFQVGSQEYSYEQFLFNTSML
VDYGVEALVDAFSRQSAGRIGGGRNIDHHVLHVAVEVIKESREMRLQPFNEYRKRFGLKP
YASFQELTGETEMAAELEELYGDIDALEFYPGLLLEKCQPNSIFGESMIEIGAPFSLKGL
LGNPICSPEYWKPSTFGGEVGSNLIKTATLKKLVCLNTKTCPYVSFRVPRSSGDDGPAAE
RRSTEL
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BDBM50331888 |
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n/a |
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Name | BDBM50331888 |
Synonyms: | 5-Chloro-2-oxo-3-(thiophene-2-carbonyl)-2,3-dihydro-indole-1-carboxylic acid amide | 5-Chloro-2-oxo-3-(thiophene-2-carbonyl)-2,3-dihydro-indole-1-carboxylic acid amide(tenidap) | CHEMBL1097558 | Tenidap |
Type | Small organic molecule |
Emp. Form. | C14H9ClN2O3S |
Mol. Mass. | 320.751 |
SMILES | NC(=O)n1c(O)c(C(=O)c2cccs2)c2cc(Cl)ccc12 |
Structure |
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