Reaction Details |
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Target | Histone deacetylase 1 |
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Ligand | BDBM50333091 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_690170 (CHEMBL1634190) |
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IC50 | 53±n/a nM |
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Citation | Auzzas, L; Larsson, A; Matera, R; Baraldi, A; Deschênes-Simard, B; Giannini, G; Cabri, W; Battistuzzi, G; Gallo, G; Ciacci, A; Vesci, L; Pisano, C Non-Natural Macrocyclic Inhibitors of Histone Deacetylases: Design, Synthesis, and Activity J Med Chem53:8387-8399 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 1 |
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Name: | Histone deacetylase 1 |
Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
Type: | Enzyme |
Mol. Mass.: | 55090.27 |
Organism: | Homo sapiens (Human) |
Description: | Q13547 |
Residue: | 482 |
Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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BDBM50333091 |
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n/a |
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Name | BDBM50333091 |
Synonyms: | (R/S)-N8-hydroxy-2-(4-methoxybenzyloxy)-N1-phenyloctanediamide | 2-(4-methoxybenzyloxy)-N8-hydroxy-N1-phenyloctanediamide | CHEMBL251011 |
Type | Small organic molecule |
Emp. Form. | C22H28N2O5 |
Mol. Mass. | 400.4681 |
SMILES | COc1ccc(COC(CCCCCC(=O)NO)C(=O)Nc2ccccc2)cc1 |w:8.8| |
Structure |
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