| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glutamate receptor 3 |
|---|
| Ligand | BDBM17662 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_690215 (CHEMBL1634345) |
|---|
| Ki | 21±n/a nM |
|---|
| Citation |  Frydenvang, K; Pickering, DS; Greenwood, JR; Krogsgaard-Larsen, N; Brehm, L; Nielsen, B; Vogensen, SB; Hald, H; Kastrup, JS; Krogsgaard-Larsen, P Biostructural and Pharmacological Studies of Bicyclic Analogues of the 3-Isoxazolol Glutamate Receptor Agonist Ibotenic Acid J Med Chem53:8354-8361 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glutamate receptor 3 |
|---|
| Name: | Glutamate receptor 3 |
|---|
| Synonyms: | GRIA3_RAT | Glur3 | Glutamate receptor 3 | Glutamate receptor ionotropic, AMPA 3 | Glutamate-AMPA | Gria3 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 100383.57 |
|---|
| Organism: | RAT |
|---|
| Description: | Glutamate-AMPA GRIA3 RAT::P19492 |
|---|
| Residue: | 888 |
|---|
| Sequence: | MGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTE
KPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVT
PSFPTDADVQFVIQMRPALKGAILSLLSYYKWEKFVYLYDTERGFSVLQAIMEAAVQNNW
QVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYM
LANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYT
SALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGM
TGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSSSSENRTIV
VTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPE
TKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFS
FLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIF
NSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIE
SAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVR
KSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGNAVNLAVLKLN
EQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEF
CYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI
|
|
|
|---|
| BDBM17662 |
|---|
| n/a |
|---|
| Name | BDBM17662 |
|---|
| Synonyms: | (2S)-2-amino-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl)propanoic acid | 2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid | AMPA | CHEMBL276815 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C7H10N2O4 |
|---|
| Mol. Mass. | 186.1653 |
|---|
| SMILES | Cc1o[nH]c(=O)c1C[C@H](N)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
