Found 222 hits with Last Name = 'krogsgaard-larsen' and Initial = 'n' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50318633
(3-benzenesulfonyl-8-piperazin-1-ylquinoline | CHEM...)Show InChI InChI=1S/C19H19N3O2S/c23-25(24,16-6-2-1-3-7-16)17-13-15-5-4-8-18(19(15)21-14-17)22-11-9-20-10-12-22/h1-8,13-14,20H,9-12H2 | PDB
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| Article PubMed
| 0.170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 1 hr by scintillation spectroscopic analysis |
J Med Chem 57: 5823-8 (2014)
Article DOI: 10.1021/jm5003759 BindingDB Entry DOI: 10.7270/Q2D79D04 |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50019704
(CHEMBL3286578)Show SMILES C(N1CCN2C(C1)Cc1c[nH]c3cccc2c13)c1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C26H25N3/c1-2-7-20(8-3-1)21-9-4-6-19(14-21)17-28-12-13-29-23(18-28)15-22-16-27-24-10-5-11-25(29)26(22)24/h1-11,14,16,23,27H,12-13,15,17-18H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.650 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]raclopride from human dopamine D2L receptor expressed in CHOK1a cell membrane after 180 mins by scintillation counting analysis |
J Med Chem 57: 5823-8 (2014)
Article DOI: 10.1021/jm5003759 BindingDB Entry DOI: 10.7270/Q2D79D04 |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50056445
(1,1-diethyl-3-[(8alpha)-6-methyl-9,10-didehydroerg...)Show SMILES CCN(CC)C(=O)N[C@@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 |c:23| Show InChI InChI=1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18+/m0/s1 | PDB
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| DrugBank Article PubMed
| 0.660 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [125]iodosulpride from human recombinant dopamine D2L receptor expressed in CHO cells after 30 mins |
J Med Chem 57: 5823-8 (2014)
Article DOI: 10.1021/jm5003759 BindingDB Entry DOI: 10.7270/Q2D79D04 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50019711
(CHEMBL3286585)Show SMILES Fc1cccc(c1)S(=O)(=O)n1cc2CC3CNCCN3c3cccc1c23 Show InChI InChI=1S/C19H18FN3O2S/c20-14-3-1-4-16(10-14)26(24,25)23-12-13-9-15-11-21-7-8-22(15)17-5-2-6-18(23)19(13)17/h1-6,10,12,15,21H,7-9,11H2 | PDB
Reactome pathway KEGG
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| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.75 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in hamster BHK cells after 60 mins by scintillation counting analysis |
J Med Chem 57: 5823-8 (2014)
Article DOI: 10.1021/jm5003759 BindingDB Entry DOI: 10.7270/Q2D79D04 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50019754
(IDALOPIRDINE | LU-AE58054)Show SMILES FC(F)C(F)(F)COc1cccc(CNCCc2c[nH]c3cc(F)ccc23)c1 Show InChI InChI=1S/C20H19F5N2O/c21-15-4-5-17-14(11-27-18(17)9-15)6-7-26-10-13-2-1-3-16(8-13)28-12-20(24,25)19(22)23/h1-5,8-9,11,19,26-27H,6-7,10,12H2 | PDB
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| Article PubMed
| 0.830 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in hamster BHK cells after 60 mins by scintillation counting analysis |
J Med Chem 57: 5823-8 (2014)
Article DOI: 10.1021/jm5003759 BindingDB Entry DOI: 10.7270/Q2D79D04 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human)) | BDBM50001786
(1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl...)Show SMILES Fc1ccc(cc1)-n1cc(C2CCN(CCN3CCNC3=O)CC2)c2cc(Cl)ccc12 Show InChI InChI=1S/C24H26ClFN4O/c25-18-1-6-23-21(15-18)22(16-30(23)20-4-2-19(26)3-5-20)17-7-10-28(11-8-17)13-14-29-12-9-27-24(29)31/h1-6,15-17H,7-14H2,(H,27,31) | PDB
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| DrugBank Article PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]mesulergine from human 5HT2C receptor in human tsA201 cells |
Bioorg Med Chem Lett 20: 5431-3 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.105 BindingDB Entry DOI: 10.7270/Q2RV0P1S |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human)) | BDBM50024204
(1H-imidazo[4,5-c]pyridine derivative | 2N-[4,7-dim...)Show SMILES CN(C)S(=O)(=O)N[C@H]1C[C@H]2[C@@H](Cc3cn(C)c4cccc2c34)N(C)C1 Show InChI InChI=1S/C18H26N4O2S/c1-20(2)25(23,24)19-13-9-15-14-6-5-7-16-18(14)12(10-21(16)3)8-17(15)22(4)11-13/h5-7,10,13,15,17,19H,8-9,11H2,1-4H3/t13-,15+,17+/m0/s1 | PDB
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| Article PubMed
| 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]5-HT from human recombinant 5-HT2C receptor expressed in HEK293 cells |
J Med Chem 57: 5823-8 (2014)
Article DOI: 10.1021/jm5003759 BindingDB Entry DOI: 10.7270/Q2D79D04 |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50241119
(7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...)Show SMILES O=c1[nH]c2cccc(N3CCN(Cc4cccc(c4)-c4ccccc4)CC3)c2o1 Show InChI InChI=1S/C24H23N3O2/c28-24-25-21-10-5-11-22(23(21)29-24)27-14-12-26(13-15-27)17-18-6-4-9-20(16-18)19-7-2-1-3-8-19/h1-11,16H,12-15,17H2,(H,25,28) | PDB
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| Article PubMed
| 2.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]nemonapride from dopamine D2L receptor (unknown origin) expressed in African green monkey COS7 cells |
J Med Chem 57: 5823-8 (2014)
Article DOI: 10.1021/jm5003759 BindingDB Entry DOI: 10.7270/Q2D79D04 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM28583
(5-chloro-N-[4-methoxy-3-(piperazin-1-yl)phenyl]-3-...)Show SMILES COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCNCC1 Show InChI InChI=1S/C20H22ClN3O3S2/c1-13-16-11-14(21)3-6-19(16)28-20(13)29(25,26)23-15-4-5-18(27-2)17(12-15)24-9-7-22-8-10-24/h3-6,11-12,22-23H,7-10H2,1-2H3 | PDB
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| Article PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in hamster BHK cells after 60 mins by scintillation counting analysis |
J Med Chem 57: 5823-8 (2014)
Article DOI: 10.1021/jm5003759 BindingDB Entry DOI: 10.7270/Q2D79D04 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50001786
(1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl...)Show SMILES Fc1ccc(cc1)-n1cc(C2CCN(CCN3CCNC3=O)CC2)c2cc(Cl)ccc12 Show InChI InChI=1S/C24H26ClFN4O/c25-18-1-6-23-21(15-18)22(16-30(23)20-4-2-19(26)3-5-20)17-7-10-28(11-8-17)13-14-29-12-9-27-24(29)31/h1-6,15-17H,7-14H2,(H,27,31) | PDB
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| DrugBank Article PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]5-LSD from human 5HT6 receptor expressed in human HeLa cells |
Bioorg Med Chem Lett 20: 5431-3 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.105 BindingDB Entry DOI: 10.7270/Q2RV0P1S |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM35254
(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)Show InChI InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3 | PDB
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| DrugBank Article PubMed
| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]5-LSD from human 5HT6 receptor expressed in human HeLa cells |
Bioorg Med Chem Lett 20: 5431-3 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.105 BindingDB Entry DOI: 10.7270/Q2RV0P1S |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50019706
(CHEMBL3286581)Show InChI InChI=1S/C19H19N3O2S/c23-25(24,16-5-2-1-3-6-16)22-13-14-11-15-12-20-9-10-21(15)17-7-4-8-18(22)19(14)17/h1-8,13,15,20H,9-12H2 | PDB
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| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in hamster BHK cells after 60 mins by scintillation counting analysis |
J Med Chem 57: 5823-8 (2014)
Article DOI: 10.1021/jm5003759 BindingDB Entry DOI: 10.7270/Q2D79D04 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50090524
(4-Amino-N-(2,6-bis-methylamino-pyridin-4-yl)-benze...)Show InChI InChI=1S/C13H17N5O2S/c1-15-12-7-10(8-13(16-2)17-12)18-21(19,20)11-5-3-9(14)4-6-11/h3-8H,14H2,1-2H3,(H3,15,16,17,18) | PDB
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| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 1 hr by scintillation spectroscopic analysis |
J Med Chem 57: 5823-8 (2014)
Article DOI: 10.1021/jm5003759 BindingDB Entry DOI: 10.7270/Q2D79D04 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human)) | BDBM50048803
(5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)et...)Show SMILES Clc1cc2NC(=O)Cc2cc1CCN1CCN(CC1)c1nsc2ccccc12 Show InChI InChI=1S/C21H21ClN4OS/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21/h1-4,11,13H,5-10,12H2,(H,23,27) | PDB
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| DrugBank Article PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]mesulergine from human 5HT2C receptor in human tsA201 cells |
Bioorg Med Chem Lett 20: 5431-3 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.105 BindingDB Entry DOI: 10.7270/Q2RV0P1S |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human)) | BDBM35254
(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)Show InChI InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3 | PDB
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| DrugBank Article PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]mesulergine from human 5HT2C receptor in human tsA201 cells |
Bioorg Med Chem Lett 20: 5431-3 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.105 BindingDB Entry DOI: 10.7270/Q2RV0P1S |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM81993
(BROMOCRIPTINE | Bromocriptine+ (GTP+) | Bromocript...)Show SMILES CC(C)C[C@@H]1N2C(=O)[C@](NC(=O)[C@H]3CN(C)[C@@H]4Cc5c(Br)[nH]c6cccc(C4=C3)c56)(O[C@@]2(O)[C@@H]2CCCN2C1=O)C(C)C |r,c:28| Show InChI InChI=1S/C32H40BrN5O5/c1-16(2)12-24-29(40)37-11-7-10-25(37)32(42)38(24)30(41)31(43-32,17(3)4)35-28(39)18-13-20-19-8-6-9-22-26(19)21(27(33)34-22)14-23(20)36(5)15-18/h6,8-9,13,16-18,23-25,34,42H,7,10-12,14-15H2,1-5H3,(H,35,39)/t18-,23-,24+,25+,31-,32+/m1/s1 | PDB
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| DrugBank PDB Article PubMed
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [125]iodosulpride from human recombinant dopamine D2L receptor expressed in CHO cells after 30 mins |
J Med Chem 57: 5823-8 (2014)
Article DOI: 10.1021/jm5003759 BindingDB Entry DOI: 10.7270/Q2D79D04 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human)) | BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8| Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3 | PDB
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| DrugBank Article PubMed
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]mesulergine from human 5HT2C receptor in human tsA201 cells |
Bioorg Med Chem Lett 20: 5431-3 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.105 BindingDB Entry DOI: 10.7270/Q2RV0P1S |
More data for this Ligand-Target Pair | |
Glutamate receptor 2
(Rattus norvegicus) | BDBM17662
((2S)-2-amino-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl...)Show InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1 | PDB MMDB
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| MMDB PDB Article PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of [3H[AMPA from rat recombinant GluA2(R)o expressed in sS9 cells |
J Med Chem 53: 8354-8361 (2010)
Article DOI: 10.1021/jm101218a BindingDB Entry DOI: 10.7270/Q20Z73HW |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50001884
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8| Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3 | PDB
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| DrugBank Article PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]5-LSD from human 5HT6 receptor expressed in human HeLa cells |
Bioorg Med Chem Lett 20: 5431-3 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.105 BindingDB Entry DOI: 10.7270/Q2RV0P1S |
More data for this Ligand-Target Pair | |
Glutamate receptor 3
(RAT) | BDBM17662
((2S)-2-amino-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl...)Show InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1 | PDB
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| PDB Article PubMed
| 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of [3H[AMPA from rat recombinant GluA3o expressed in sS9 cells |
J Med Chem 53: 8354-8361 (2010)
Article DOI: 10.1021/jm101218a BindingDB Entry DOI: 10.7270/Q20Z73HW |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50019707
(CHEMBL3286399)Show InChI InChI=1S/C20H21N3O2S/c1-14-5-2-3-8-19(14)26(24,25)23-13-15-11-16-12-21-9-10-22(16)17-6-4-7-18(23)20(15)17/h2-8,13,16,21H,9-12H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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Similars
| Article PubMed
| 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in hamster BHK cells after 60 mins by scintillation counting analysis |
J Med Chem 57: 5823-8 (2014)
Article DOI: 10.1021/jm5003759 BindingDB Entry DOI: 10.7270/Q2D79D04 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human)) | BDBM50130293
(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)Show SMILES Clc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl Show InChI InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29) | PDB
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| DrugBank Article PubMed
| 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]mesulergine from human 5HT2C receptor in human tsA201 cells |
Bioorg Med Chem Lett 20: 5431-3 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.105 BindingDB Entry DOI: 10.7270/Q2RV0P1S |
More data for this Ligand-Target Pair | |
Glutamate receptor 1
(Rattus norvegicus (Rat)) | BDBM17662
((2S)-2-amino-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl...)Show InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1 | PDB
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| 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of [3H[AMPA from rat recombinant GluA1o expressed in sS9 cells |
J Med Chem 53: 8354-8361 (2010)
Article DOI: 10.1021/jm101218a BindingDB Entry DOI: 10.7270/Q20Z73HW |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50346249
(7-(2-Methoxy-phenylsulfanyl)-1,2,3,4,10,10a-hexahy...)Show InChI InChI=1S/C18H20N2OS/c1-21-17-4-2-3-5-18(17)22-15-7-6-13-10-14-12-19-8-9-20(14)16(13)11-15/h2-7,11,14,19H,8-10,12H2,1H3 | PDB
Reactome pathway KEGG
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Similars
| Article PubMed
| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]5-LSD from human 5HT6 receptor expressed in human HeLa cells |
Bioorg Med Chem Lett 20: 5431-3 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.105 BindingDB Entry DOI: 10.7270/Q2RV0P1S |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50019730
(CHEMBL3286591)Show SMILES COc1cccc(c1)S(=O)(=O)n1cc2CC3CNCCN3c3cccc1c23 Show InChI InChI=1S/C20H21N3O3S/c1-26-16-4-2-5-17(11-16)27(24,25)23-13-14-10-15-12-21-8-9-22(15)18-6-3-7-19(23)20(14)18/h2-7,11,13,15,21H,8-10,12H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in hamster BHK cells after 60 mins by scintillation counting analysis |
J Med Chem 57: 5823-8 (2014)
Article DOI: 10.1021/jm5003759 BindingDB Entry DOI: 10.7270/Q2D79D04 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50019708
(CHEMBL3286582)Show SMILES Cc1cccc(c1)S(=O)(=O)n1cc2CC3CNCCN3c3cccc1c23 Show InChI InChI=1S/C20H21N3O2S/c1-14-4-2-5-17(10-14)26(24,25)23-13-15-11-16-12-21-8-9-22(16)18-6-3-7-19(23)20(15)18/h2-7,10,13,16,21H,8-9,11-12H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in hamster BHK cells after 60 mins by scintillation counting analysis |
J Med Chem 57: 5823-8 (2014)
Article DOI: 10.1021/jm5003759 BindingDB Entry DOI: 10.7270/Q2D79D04 |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50019700
(CHEMBL3286574)Show InChI InChI=1S/C18H25N3/c1-13(2)6-7-20-8-9-21-15(12-20)10-14-11-19-16-4-3-5-17(21)18(14)16/h3-5,11,13,15,19H,6-10,12H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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Similars
| Article PubMed
| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]raclopride from human dopamine D2L receptor expressed in CHOK1a cell membrane after 180 mins by scintillation counting analysis |
J Med Chem 57: 5823-8 (2014)
Article DOI: 10.1021/jm5003759 BindingDB Entry DOI: 10.7270/Q2D79D04 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50019716
(CHEMBL3286590)Show SMILES COc1ccccc1S(=O)(=O)n1cc2CC3CNCCN3c3cccc1c23 Show InChI InChI=1S/C20H21N3O3S/c1-26-18-7-2-3-8-19(18)27(24,25)23-13-14-11-15-12-21-9-10-22(15)16-5-4-6-17(23)20(14)16/h2-8,13,15,21H,9-12H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in hamster BHK cells after 60 mins by scintillation counting analysis |
J Med Chem 57: 5823-8 (2014)
Article DOI: 10.1021/jm5003759 BindingDB Entry DOI: 10.7270/Q2D79D04 |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50017543
((6aR,9R,10aR)-9-Methylsulfanylmethyl-7-propyl-4,6,...)Show SMILES CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3cccc2c13 |r| Show InChI InChI=1S/C19H26N2S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3/t13-,16-,18-/m1/s1 | PDB
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| DrugBank Article PubMed
| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [125]iodosulpride from human recombinant dopamine D2L receptor expressed in CHO cells after 30 mins |
J Med Chem 57: 5823-8 (2014)
Article DOI: 10.1021/jm5003759 BindingDB Entry DOI: 10.7270/Q2D79D04 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50019712
(CHEMBL3286586)Show SMILES Fc1ccc(cc1)S(=O)(=O)n1cc2CC3CNCCN3c3cccc1c23 Show InChI InChI=1S/C19H18FN3O2S/c20-14-4-6-16(7-5-14)26(24,25)23-12-13-10-15-11-21-8-9-22(15)17-2-1-3-18(23)19(13)17/h1-7,12,15,21H,8-11H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in hamster BHK cells after 60 mins by scintillation counting analysis |
J Med Chem 57: 5823-8 (2014)
Article DOI: 10.1021/jm5003759 BindingDB Entry DOI: 10.7270/Q2D79D04 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human)) | BDBM50001885
((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)Show SMILES Cc1nc2CCCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12 Show InChI InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3 | PDB
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| DrugBank Article PubMed
| 33 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]mesulergine from human 5HT2C receptor in human tsA201 cells |
Bioorg Med Chem Lett 20: 5431-3 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.105 BindingDB Entry DOI: 10.7270/Q2RV0P1S |
More data for this Ligand-Target Pair | |
Glutamate receptor 4
(Rattus norvegicus) | BDBM17662
((2S)-2-amino-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl...)Show InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1 | PDB MMDB
Reactome pathway KEGG
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| MMDB PDB Article PubMed
| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of [3H[AMPA from rat recombinant GluA4o expressed in sS9 cells |
J Med Chem 53: 8354-8361 (2010)
Article DOI: 10.1021/jm101218a BindingDB Entry DOI: 10.7270/Q20Z73HW |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human)) | BDBM50346249
(7-(2-Methoxy-phenylsulfanyl)-1,2,3,4,10,10a-hexahy...)Show InChI InChI=1S/C18H20N2OS/c1-21-17-4-2-3-5-18(17)22-15-7-6-13-10-14-12-19-8-9-20(14)16(13)11-15/h2-7,11,14,19H,8-10,12H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]mesulergine from human 5HT2C receptor in human tsA201 cells |
Bioorg Med Chem Lett 20: 5431-3 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.105 BindingDB Entry DOI: 10.7270/Q2RV0P1S |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50019714
(CHEMBL3286588)Show SMILES O=S(=O)(C1=CC=C=C=C1)n1cc2CC3CNCCN3c3cccc1c23 |t:3,(30.87,-26.22,;29.38,-26.62,;30.48,-27.71,;28.35,-27.78,;26.85,-27.45,;25.81,-28.6,;26.29,-30.07,;27.81,-30.38,;28.84,-29.23,;28.91,-25.16,;29.81,-23.92,;28.78,-22.39,;28.79,-20.85,;27.46,-20.08,;27.46,-18.54,;26.12,-17.76,;24.79,-18.54,;24.79,-20.08,;26.12,-20.85,;26.12,-22.38,;24.8,-23.14,;24.79,-24.67,;26.12,-25.44,;27.45,-24.69,;27.45,-23.15,)| Show InChI InChI=1S/C19H17N3O2S/c23-25(24,16-5-2-1-3-6-16)22-13-14-11-15-12-20-9-10-21(15)17-7-4-8-18(22)19(14)17/h2,4-8,13,15,20H,9-12H2 | PDB
Reactome pathway KEGG
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| Article PubMed
| 47 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in hamster BHK cells after 60 mins by scintillation counting analysis |
J Med Chem 57: 5823-8 (2014)
Article DOI: 10.1021/jm5003759 BindingDB Entry DOI: 10.7270/Q2D79D04 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human)) | BDBM50346246
(7-o-Tolylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazin...)Show InChI InChI=1S/C18H20N2S/c1-13-4-2-3-5-18(13)21-16-7-6-14-10-15-12-19-8-9-20(15)17(14)11-16/h2-7,11,15,19H,8-10,12H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 49 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]mesulergine from human 5HT2C receptor in human tsA201 cells |
Bioorg Med Chem Lett 20: 5431-3 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.105 BindingDB Entry DOI: 10.7270/Q2RV0P1S |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human)) | BDBM50346252
(7-(2-Fluoro-phenylsulfanyl)-1,2,3,4,10,10a-hexahyd...)Show InChI InChI=1S/C17H17FN2S/c18-15-3-1-2-4-17(15)21-14-6-5-12-9-13-11-19-7-8-20(13)16(12)10-14/h1-6,10,13,19H,7-9,11H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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Similars
| Article PubMed
| 49 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]mesulergine from human 5HT2C receptor in human tsA201 cells |
Bioorg Med Chem Lett 20: 5431-3 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.105 BindingDB Entry DOI: 10.7270/Q2RV0P1S |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50346247
(7-m-Tolylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazin...)Show InChI InChI=1S/C18H20N2S/c1-13-3-2-4-16(9-13)21-17-6-5-14-10-15-12-19-7-8-20(15)18(14)11-17/h2-6,9,11,15,19H,7-8,10,12H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]5-LSD from human 5HT6 receptor expressed in human HeLa cells |
Bioorg Med Chem Lett 20: 5431-3 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.105 BindingDB Entry DOI: 10.7270/Q2RV0P1S |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 1
(Homo sapiens (Human)) | BDBM50200526
(CHEMBL1234118)Show SMILES OC(=O)[C@@H]1CC(F)(F)CN1C[C@H]1CC[C@H]2CN[C@@H](C[C@H]2C1)C(O)=O |r| Show InChI InChI=1S/C16H24F2N2O4/c17-16(18)5-13(15(23)24)20(8-16)7-9-1-2-10-6-19-12(14(21)22)4-11(10)3-9/h9-13,19H,1-8H2,(H,21,22)(H,23,24)/t9-,10-,11+,12-,13-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
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| PDB Article PubMed
| 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
McGill University
Curated by ChEMBL
| Assay Description Displacement of [3H]kainate from human GluK1 expressed in HEK293 cell membranes after 60 mins by scintillation counting method |
J Med Chem 60: 441-457 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01516 BindingDB Entry DOI: 10.7270/Q2G44SJJ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50019701
(CHEMBL3286575)Show InChI InChI=1S/C20H27N3/c1-2-5-15(6-3-1)13-22-9-10-23-17(14-22)11-16-12-21-18-7-4-8-19(23)20(16)18/h4,7-8,12,15,17,21H,1-3,5-6,9-11,13-14H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 54 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]raclopride from human dopamine D2L receptor expressed in CHOK1a cell membrane after 180 mins by scintillation counting analysis |
J Med Chem 57: 5823-8 (2014)
Article DOI: 10.1021/jm5003759 BindingDB Entry DOI: 10.7270/Q2D79D04 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human)) | BDBM50346251
(7-(4-Methoxy-phenylsulfanyl)-1,2,3,4,10,10a-hexahy...)Show InChI InChI=1S/C18H20N2OS/c1-21-15-3-6-16(7-4-15)22-17-5-2-13-10-14-12-19-8-9-20(14)18(13)11-17/h2-7,11,14,19H,8-10,12H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 57 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]mesulergine from human 5HT2C receptor in human tsA201 cells |
Bioorg Med Chem Lett 20: 5431-3 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.105 BindingDB Entry DOI: 10.7270/Q2RV0P1S |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human)) | BDBM50346253
(7-(4-Fluoro-phenylsulfanyl)-1,2,3,4,10,10a-hexahyd...)Show InChI InChI=1S/C17H17FN2S/c18-13-2-5-15(6-3-13)21-16-4-1-12-9-14-11-19-7-8-20(14)17(12)10-16/h1-6,10,14,19H,7-9,11H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 61 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]mesulergine from human 5HT2C receptor in human tsA201 cells |
Bioorg Med Chem Lett 20: 5431-3 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.105 BindingDB Entry DOI: 10.7270/Q2RV0P1S |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50048803
(5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)et...)Show SMILES Clc1cc2NC(=O)Cc2cc1CCN1CCN(CC1)c1nsc2ccccc12 Show InChI InChI=1S/C21H21ClN4OS/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21/h1-4,11,13H,5-10,12H2,(H,23,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem
Patents
Similars
| DrugBank Article PubMed
| 61 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]5-LSD from human 5HT6 receptor expressed in human HeLa cells |
Bioorg Med Chem Lett 20: 5431-3 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.105 BindingDB Entry DOI: 10.7270/Q2RV0P1S |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human)) | BDBM50346248
(7-p-Tolylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazin...)Show InChI InChI=1S/C18H20N2S/c1-13-2-5-16(6-3-13)21-17-7-4-14-10-15-12-19-8-9-20(15)18(14)11-17/h2-7,11,15,19H,8-10,12H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 68 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]mesulergine from human 5HT2C receptor in human tsA201 cells |
Bioorg Med Chem Lett 20: 5431-3 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.105 BindingDB Entry DOI: 10.7270/Q2RV0P1S |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human)) | BDBM50346245
(1-(3-(4-methoxyphenylthio)phenyl)piperazine | CHEM...)Show InChI InChI=1S/C17H20N2OS/c1-20-15-5-7-16(8-6-15)21-17-4-2-3-14(13-17)19-11-9-18-10-12-19/h2-8,13,18H,9-12H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 74 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]mesulergine from human 5HT2C receptor in human tsA201 cells |
Bioorg Med Chem Lett 20: 5431-3 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.105 BindingDB Entry DOI: 10.7270/Q2RV0P1S |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human)) | BDBM50346247
(7-m-Tolylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazin...)Show InChI InChI=1S/C18H20N2S/c1-13-3-2-4-16(9-13)21-17-6-5-14-10-15-12-19-7-8-20(15)18(14)11-17/h2-6,9,11,15,19H,7-8,10,12H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 77 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]mesulergine from human 5HT2C receptor in human tsA201 cells |
Bioorg Med Chem Lett 20: 5431-3 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.105 BindingDB Entry DOI: 10.7270/Q2RV0P1S |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50346251
(7-(4-Methoxy-phenylsulfanyl)-1,2,3,4,10,10a-hexahy...)Show InChI InChI=1S/C18H20N2OS/c1-21-15-3-6-16(7-4-15)22-17-5-2-13-10-14-12-19-8-9-20(14)18(13)11-17/h2-7,11,14,19H,8-10,12H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 78 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]5-LSD from human 5HT6 receptor expressed in human HeLa cells |
Bioorg Med Chem Lett 20: 5431-3 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.105 BindingDB Entry DOI: 10.7270/Q2RV0P1S |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50346246
(7-o-Tolylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazin...)Show InChI InChI=1S/C18H20N2S/c1-13-4-2-3-5-18(13)21-16-7-6-14-10-15-12-19-8-9-20(15)17(14)11-16/h2-7,11,15,19H,8-10,12H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 81 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]5-LSD from human 5HT6 receptor expressed in human HeLa cells |
Bioorg Med Chem Lett 20: 5431-3 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.105 BindingDB Entry DOI: 10.7270/Q2RV0P1S |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human)) | BDBM50346254
(7-(2-Trifluoromethyl-phenylsulfanyl)-1,2,3,4,10,10...)Show InChI InChI=1S/C18H17F3N2S/c19-18(20,21)15-3-1-2-4-17(15)24-14-6-5-12-9-13-11-22-7-8-23(13)16(12)10-14/h1-6,10,13,22H,7-9,11H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 83 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]mesulergine from human 5HT2C receptor in human tsA201 cells |
Bioorg Med Chem Lett 20: 5431-3 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.105 BindingDB Entry DOI: 10.7270/Q2RV0P1S |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human)) | BDBM50346244
(1-(3-(phenylthio)phenyl)piperazine | CHEMBL1782355)Show InChI InChI=1S/C16H18N2S/c1-2-6-15(7-3-1)19-16-8-4-5-14(13-16)18-11-9-17-10-12-18/h1-8,13,17H,9-12H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 91 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]mesulergine from human 5HT2C receptor in human tsA201 cells |
Bioorg Med Chem Lett 20: 5431-3 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.105 BindingDB Entry DOI: 10.7270/Q2RV0P1S |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50019709
(CHEMBL3286583)Show SMILES Cc1ccc(cc1)S(=O)(=O)n1cc2CC3CNCCN3c3cccc1c23 Show InChI InChI=1S/C20H21N3O2S/c1-14-5-7-17(8-6-14)26(24,25)23-13-15-11-16-12-21-9-10-22(16)18-3-2-4-19(23)20(15)18/h2-8,13,16,21H,9-12H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 95 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in hamster BHK cells after 60 mins by scintillation counting analysis |
J Med Chem 57: 5823-8 (2014)
Article DOI: 10.1021/jm5003759 BindingDB Entry DOI: 10.7270/Q2D79D04 |
More data for this Ligand-Target Pair | |