| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium-dependent serotonin transporter |
|---|
| Ligand | BDBM50333431 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_698907 (CHEMBL1645847) |
|---|
| Ki | >4710±n/a nM |
|---|
| Citation |  Pettersson, M; Campbell, BM; Dounay, AB; Gray, DL; Xie, L; O'Donnell, CJ; Stratman, NC; Zoski, K; Drummond, E; Bora, G; Probert, A; Whisman, T Design, synthesis, and pharmacological evaluation of azetedine and pyrrolidine derivatives as dual norepinephrine reuptake inhibitors and 5-HT(1A) partial agonists. Bioorg Med Chem Lett21:865-8 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium-dependent serotonin transporter |
|---|
| Name: | Sodium-dependent serotonin transporter |
|---|
| Synonyms: | 5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4 |
|---|
| Type: | Multi-pass membrane protein |
|---|
| Mol. Mass.: | 70322.51 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P31645 |
|---|
| Residue: | 630 |
|---|
| Sequence: | METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT
LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
PGTFKERIIKSITPETPTEIPCGDIRLNAV
|
|
|
|---|
| BDBM50333431 |
|---|
| n/a |
|---|
| Name | BDBM50333431 |
|---|
| Synonyms: | 3-(2-fluoro-6-(2-fluorophenoxy)phenoxy)azetidine | CHEMBL1645598 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H13F2NO2 |
|---|
| Mol. Mass. | 277.266 |
|---|
| SMILES | Fc1ccccc1Oc1cccc(F)c1OC1CNC1 |
|---|
| Structure | 
|
|---|
Search and Browse
