| Reaction Details |
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 | Report a problem with these data |
| Target | Ribosomal protein S6 kinase beta-1 |
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| Ligand | BDBM50333489 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_698950 (CHEMBL1646054) |
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| IC50 | 9000±n/a nM |
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| Citation |  Ye, P; Kuhn, C; Juan, M; Sharma, R; Connolly, B; Alton, G; Liu, H; Stanton, R; Kablaoui, NM Potent and selective thiophene urea-templated inhibitors of S6K. Bioorg Med Chem Lett21:849-52 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ribosomal protein S6 kinase beta-1 |
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| Name: | Ribosomal protein S6 kinase beta-1 |
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| Synonyms: | 70 kDa ribosomal protein S6 kinase 1 | 70 kDa ribosomal protein S6 kinase 1 (P70s6k) | 70 kDa ribosomal protein kinase (p70S6K) | KS6B1_HUMAN | Protein kinase 70S6K (T412E) | RAC-alpha serine/threonine-protein kinase/Ribosomal protein S6 kinase beta-1 | RPS6KB1 | Ribosomal protein S6 kinase (P70S6K) | Ribosomal protein S6 kinase I | S6K1 | STK14A | p70 S6 ribosomal protein kinase 1 | p70S6K1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 59139.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | His-tagged S6K1. |
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| Residue: | 525 |
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| Sequence: | MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG
PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF
AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL
FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC
KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK
TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL
LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLE
SVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSG
IEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
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| BDBM50333489 |
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| n/a |
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| Name | BDBM50333489 |
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| Synonyms: | 1-[5-tert-Butyl-3-(1,1-dioxo-1lambda*6*-thiomorpholine-4-carbonyl)-thiophen-2-yl]-3-[4-(pyridin-3-yloxy)-phenyl]-urea | CHEMBL1641784 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H28N4O5S2 |
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| Mol. Mass. | 528.644 |
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| SMILES | CC(C)(C)c1cc(C(=O)N2CCS(=O)(=O)CC2)c(NC(=O)Nc2ccc(Oc3cccnc3)cc2)s1 |
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| Structure | 
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