| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50333520 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_699500 (CHEMBL1647755) |
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| Ki | 3.5±n/a nM |
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| Citation |  Xiao, D; Palani, A; Sofolarides, M; Huang, Y; Aslanian, R; Vaccaro, H; Hong, L; McKittrick, B; West, RE; Williams, SM; Wu, RL; Hwa, J; Sondey, C; Lachowicz, J Discovery of a series of potent arylthiadiazole H(3) antagonists. Bioorg Med Chem Lett21:861-4 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48691.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
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| Residue: | 445 |
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| Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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| BDBM50333520 |
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| n/a |
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| Name | BDBM50333520 |
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| Synonyms: | 2-(1,4'-bipiperidin-1'-yl)-5-(6-methoxypyridin-2-yl)-1,3,4-thiadiazole | CHEMBL1641837 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H25N5OS |
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| Mol. Mass. | 359.489 |
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| SMILES | COc1cccc(n1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1 |
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| Structure | 
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