Reaction Details |
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Target | Histamine H3 receptor |
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Ligand | BDBM50333535 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_699500 (CHEMBL1647755) |
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Ki | 36.4±n/a nM |
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Citation | Xiao, D; Palani, A; Sofolarides, M; Huang, Y; Aslanian, R; Vaccaro, H; Hong, L; McKittrick, B; West, RE; Williams, SM; Wu, RL; Hwa, J; Sondey, C; Lachowicz, J Discovery of a series of potent arylthiadiazole H(3) antagonists. Bioorg Med Chem Lett21:861-4 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histamine H3 receptor |
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Name: | Histamine H3 receptor |
Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 48691.47 |
Organism: | Homo sapiens (Human) |
Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
Residue: | 445 |
Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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BDBM50333535 |
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n/a |
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Name | BDBM50333535 |
Synonyms: | 4-(5-(1,4'-bipiperidin-1'-yl)-1,3,4-thiadiazol-2-yl)benzonitrile | CHEMBL1641852 |
Type | Small organic molecule |
Emp. Form. | C19H23N5S |
Mol. Mass. | 353.484 |
SMILES | N#Cc1ccc(cc1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1 |
Structure |
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