| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 2D6 |
|---|
| Ligand | BDBM50333868 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_699807 (CHEMBL1645653) |
|---|
| IC50 | >50000±n/a nM |
|---|
| Citation |  Gallant, M; Beaulieu, C; Berthelette, C; Colucci, J; Crackower, MA; Dalton, C; Denis, D; Ducharme, Y; Friesen, RW; Guay, D; Gervais, FG; Hamel, M; Houle, R; Krawczyk, CM; Kosjek, B; Lau, S; Leblanc, Y; Lee, EE; Levesque, JF; Mellon, C; Molinaro, C; Mullet, W; O'Neill, GP; O'Shea, P; Sawyer, N; Sillaots, S; Simard, D; Slipetz, D; Stocco, R; Sørensen, D; Truong, VL; Wong, E; Wu, J; Zaghdane, H; Wang, Z Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases. Bioorg Med Chem Lett21:288-93 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 2D6 |
|---|
| Name: | Cytochrome P450 2D6 |
|---|
| Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 55774.82 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P10635 |
|---|
| Residue: | 497 |
|---|
| Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
|
|
|
|---|
| BDBM50333868 |
|---|
| n/a |
|---|
| Name | BDBM50333868 |
|---|
| Synonyms: | (R)-2-(3-fluoro-7-(4-fluoro-N-methylphenylsulfonamido)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetic acid | CHEMBL1643773 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H20F2N2O4S |
|---|
| Mol. Mass. | 434.456 |
|---|
| SMILES | CN([C@@H]1CCc2c(CC(O)=O)c3ccc(F)cc3n2C1)S(=O)(=O)c1ccc(F)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
