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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Progesterone receptor | ||
| Ligand | BDBM50334052 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_701246 (CHEMBL1648866) | ||
| Ki | 420±n/a nM | ||
| Citation |  Roach, SL; Higuchi, RI; Hudson, AR; Adams, ME; Syka, PM; Mais, DE; Miner, JN; Marschke, KB; Zhi, L Tetrahydroquinoline glucocorticoid receptor agonists: discovery of a 3-hydroxyl for improving receptor selectivity. Bioorg Med Chem Lett21:168-71 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Progesterone receptor | |||
| Name: | Progesterone receptor | ||
| Synonyms: | NR3C3 | Nuclear receptor subfamily 3 group C member 3 | PGR | PR | PRGR_HUMAN | progesterone | ||
| Type: | Protein | ||
| Mol. Mass.: | 98979.52 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P06401 | ||
| Residue: | 933 | ||
| Sequence: |
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| BDBM50334052 | |||
| n/a | |||
| Name | BDBM50334052 | ||
| Synonyms: | 5-chloro-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-4-(3-methylbut-2-enyl)-1,2-dihydroquinolin-3(4H)-one | CHEMBL1644757 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H29ClN2O | ||
| Mol. Mass. | 420.974 | ||
| SMILES | CC(C)=CCC1(C)C(=O)C(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2cc[nH]c12 |(32.68,-5.02,;31.14,-5.03,;30.36,-3.7,;30.38,-6.37,;28.84,-6.39,;28.08,-7.73,;27.3,-6.39,;29.42,-8.5,;30.75,-7.73,;29.42,-10.04,;30.18,-11.37,;30.9,-9.64,;28.08,-10.81,;26.76,-10.05,;25.43,-10.83,;25.43,-12.37,;24.09,-10.06,;24.09,-8.52,;25.42,-7.75,;25.41,-6.21,;26.75,-8.51,;22.76,-7.75,;22.76,-6.2,;21.42,-5.44,;20.1,-6.21,;20.09,-7.74,;18.94,-8.78,;19.56,-10.19,;21.1,-10.03,;21.43,-8.52,)| | ||
| Structure | 
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