Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetAurora kinase A
LigandBDBM50318603
Substrate/Competitorn/a
Meas. Tech.ChEMBL_715420
IC50 10±n/a nM
Citation Lan PChen WNChen WM Molecular modeling studies on imidazo[4,5-b]pyridine derivatives as Aurora A kinase inhibitors using 3D-QSAR and docking approaches. Eur J Med Chem 46:77-94 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aurora kinase A
Name:Aurora kinase A
Synonyms:ARK1 | AURKA | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1
Type:Serine/threonine-protein kinase
Mol. Mass.:45830.98
Organism:Homo sapiens (Human)
Description:n/a
Residue:403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50318603
n/a
NameBDBM50318603
Synonyms:3-((4-(6-Bromo-2-(4-(piperazin-1-ylmethyl)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole | CHEMBL1085607
TypeSmall organic molecule
Emp. Form.C26H31BrN8O
Mol. Mass.551.481
SMILESCc1cc(CN2CCN(CC2)c2c(Br)cnc3nc([nH]c23)-c2ccc(CN3CCNCC3)cc2)no1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: